RESUMEN
This report describes the unique development of pulmonary vascular dilatation and hypoxemia associated with a portosystemic shunt in a pediatric liver transplant recipient. Ligation of the shunt resulted in resolution of hypoxemia. The outcome suggests that hepatic venous return to the pulmonary circulation is important in maintaining normal pulmonary vascular caliber.
Asunto(s)
Hipoxia/terapia , Trasplante de Hígado , Derivación Portosistémica Quirúrgica/efectos adversos , Complicaciones Posoperatorias/terapia , Niño , Femenino , Humanos , Hipoxia/etiología , Ligadura , Complicaciones Posoperatorias/etiología , Inducción de RemisiónAsunto(s)
Rechazo de Injerto , Trasplante de Hígado , Infecciones por Paramyxoviridae/etiología , Neumonía Viral/etiología , Complicaciones Posoperatorias/etiología , Líquido del Lavado Bronquioalveolar/microbiología , Femenino , Estudios de Seguimiento , Humanos , Terapia de Inmunosupresión/efectos adversos , Lactante , Virus de la Parainfluenza 3 Humana/aislamiento & purificación , Infecciones por Paramyxoviridae/tratamiento farmacológico , Infecciones por Paramyxoviridae/microbiología , Neumonía Viral/tratamiento farmacológico , Neumonía Viral/microbiología , Ribavirina/uso terapéuticoRESUMEN
A double-masked, controlled clinical trial was conducted in Guatemala to assess the safety and efficacy of diethylcarbamazine (DEC) lotion as compared to placebo lotion in the treatment of onchocerciasis. One hundred eighty-seven people were enrolled in this study and were followed for two months. Lotion was applied daily for seven days, then weekly for seven weeks. The decrease in mean microfilarial counts per skin snip was significantly greater in those receiving DEC lotion than for those receiving placebo lotion. The proportionate reduction in microfilarial counts was similar for people with light, moderate, or heavy microfilarial loads. Side effects were mainly related to skin changes, fever, and malaise, and occurred in nearly one-third of the people receiving DEC lotion. These reactions occurred almost as commonly in those people who were lightly infected as in those who had moderate or heavy infections.