RESUMEN
Epithalamine produces a dose-dependent antioxidant effect in patients in the early stage of diabetic retinopathy (DR). Retinalamine normalizes the parameters of local hemostatic potential only under the conditions of completely restored antioxidant activity and lipid hydroperoxide level. Combined administration of epithalamine and retinalamine is recommended for correcting pathological changes of the hemostatic and antioxidant potential and for preventing the blood vessel damage in patients in the early stage of DR.
Asunto(s)
Antioxidantes/administración & dosificación , Retinopatía Diabética/tratamiento farmacológico , Fármacos Hematológicos/administración & dosificación , Péptidos/administración & dosificación , Adulto , Anticoagulantes/administración & dosificación , Relación Dosis-Respuesta a Droga , Femenino , Fibrinolíticos/administración & dosificación , Homeostasis/efectos de los fármacos , Humanos , Inyecciones Intramusculares , Peroxidación de Lípido/efectos de los fármacos , Masculino , Persona de Mediana Edad , Oxidación-Reducción/efectos de los fármacos , Inhibidores de Agregación Plaquetaria/administración & dosificaciónRESUMEN
Fifty patients with insulin-dependent diabetes mellitus (DM) and with the disease record ranging from 6 months to 5 years and 30 virtually healthy persons were examined. The follow-up varied from 1.5 to 2 years. The obtained results were made use of to formulate the below diagnostic criterion: a simultaneous increase of the levels of the coagulation activity of the lachrymal fluid (LF) and of the glucose concentration in LF with at least one such phenomenon being registered in one eye and a total asymmetry of more than 0.75 are indicative of diabetic retinopathy or of the possibility it would develop. The mentioned diagnostic criterion can be applied for detecting the risk groups among the DM patients.
Asunto(s)
Diabetes Mellitus Tipo 1/complicaciones , Retinopatía Diabética/diagnóstico , Glucosa/análisis , Lágrimas , Adulto , Glucemia/análisis , Retinopatía Diabética/sangre , Electrorretinografía , Angiografía con Fluoresceína , Estudios de Seguimiento , Humanos , Persona de Mediana Edad , Oftalmoscopía , Pronóstico , Factores de Riesgo , Lágrimas/química , Lágrimas/fisiología , Factores de TiempoRESUMEN
A comparative estimate of the hormonal status and coagulatory activity was carried out in patients with diabetes mellitus at the functional and subclinical stages of diabetic retinopathy and in those without signs of diabetic retinopathy. In all patients, the blood level of hormones was elevated, while in patients with functional and subclinical stages of diabetic retinopathy, the changes in hormonal status were accompanied by increased local and systemic potentials, disturbed microcirculation, and decreased functional activity of the retina outer layers. The increased hormone level affected the hemostatic potentials and induced their elevation at a certain stage. The reliably increased local hemostatic potential was one of the first signs of pathological action of the increased hormone level, while the increase of systemic hemostatic potential was unreliable. The combination of elevated blood level of hormones and coagulatory activity of the tear fluid is a marker fore revealing the group of risk for development of diabetic retinopathy in patients with diabetes mellitus.