Asunto(s)
Recien Nacido Prematuro/fisiología , Meconio , Humanos , Recién Nacido , Factores de TiempoRESUMEN
We reviewed the results of imaging studies on 111 children and adolescents with partial epilepsy to determine which imaging procedure had the greatest sensitivity and specificity for partial epilepsy in this age range. All cases were classified as idiopathic, lesional, and cryptogenic epilepsy based on the 1989 International League Against Epilepsy Classification. All patients had magnetic resonance imaging (MRI) and 98 also had computed tomography (CT). Thirty patients with negative CT had MRI lesions that were most likely the cause of the epilepsy, and the initial diagnosis of cryptogenic partial epilepsy was changed to lesional partial epilepsy. We concluded that CT use is unwarrantedly common. MRI should be considered the procedure of first choice. CT has a complementary role, and functional neuroimaging should be encouraged.
Asunto(s)
Epilepsias Parciales/diagnóstico , Imagen por Resonancia Magnética , Tomografía Computarizada por Rayos X , Adolescente , Factores de Edad , Encefalopatías/diagnóstico , Encefalopatías/diagnóstico por imagen , Niño , Preescolar , Epilepsias Parciales/diagnóstico por imagen , Epilepsia/diagnóstico , Epilepsia/diagnóstico por imagen , Femenino , Humanos , Lactante , Imagen por Resonancia Magnética/estadística & datos numéricos , Masculino , Sensibilidad y Especificidad , Tomografía Computarizada de Emisión de Fotón Único , Tomografía Computarizada por Rayos X/estadística & datos numéricosRESUMEN
A series of 2-arylamino-1,3,4-thiadiazole derivatives was synthesized with the aim to find new antihypertensive compounds. The antihypertensive activity of some of these compounds was examined intraperitoneally in conscious spontaneously hypertensive rats (SHR). The tested compounds showed activity, but none of these possessed a higher potency than the reference substance guanabenz.