RESUMEN
To study the impact of Opisthorchis infestation on the upper digestive tract and small bowel in chronic inflammatory bowel diseases, the authors examined 164 patients with inflammatory bowel diseases, including 71 patients with ulcerative colitis and 45 with Crohn's disease without parasitosis and 48 with chronic opisthorchiasis (31 with ulcerative colitis and 17 with Crohn's disease). A control group consisted of 20 healthy individuals and 20 patients with chronic opisthorchiasis. A diagnosis was established by colonofibroscopy and a morphological study of colonic biopsy specimens. Gastric mucosal atrophic changes and motor evacuatory disorders as duodenogastric reflux were significantly more frequently encountered in inflammatory bowel diseases concurrent with chronic opisthorchiasis. The presence of Opisthorchis infestation significantly worsened fat and carbohydrate malabsorption in the small bowel in inflammatory bowel diseases.
Asunto(s)
Reflujo Duodenogástrico/fisiopatología , Enfermedades Inflamatorias del Intestino/fisiopatología , Intestino Delgado/fisiopatología , Opistorquiasis/fisiopatología , Estómago/fisiopatología , Adulto , Anciano , Animales , Atrofia/patología , Metabolismo de los Hidratos de Carbono , Enfermedad Crónica , Reflujo Duodenogástrico/etiología , Reflujo Duodenogástrico/patología , Femenino , Mucosa Gástrica/patología , Mucosa Gástrica/fisiopatología , Humanos , Enfermedades Inflamatorias del Intestino/complicaciones , Enfermedades Inflamatorias del Intestino/patología , Mucosa Intestinal/patología , Mucosa Intestinal/fisiopatología , Masculino , Persona de Mediana Edad , Opistorquiasis/complicaciones , Opistorquiasis/patología , PorcinosRESUMEN
Fecal elastase-1 was measured in 38 patients with ulcerative colitis to evaluate the functional state of pancreas by enzyme immunoassay with the use of monoclonal antibodies. It was shown that absolute and relative fecal elastase-1 levels in patients with chronic inflammatory intestinal disorders significantly decreased with increased severity of the disease.