RESUMEN

We analyzed the urine proteome in 14 healthy volunteers who underwent a 5-day dry immersion using proteomic analysis methods and bioinformatics approach. We identified 9 proteins related to cardiovascular system. It was shown that 5-day dry immersion modifies urine proteomic profile indicating renal, endocrine, circulatory and metabolic changes. Most of these changes are characterized by both a very rapid onset and very rapid restoration within return to normal conditions.

Asunto(s)

Sistema Cardiovascular/metabolismo , Biosíntesis de Proteínas/genética , Proteínas/metabolismo , Orina , Adulto , Sistema Cardiovascular/patología , Humanos , Inmersión/fisiopatología , Masculino , Proteoma