Asunto(s)
Enfermedades Fetales/inmunología , Inmunización/métodos , Infecciones Estafilocócicas/inmunología , Toxoide Estafilocócico/inmunología , Animales , Antitoxinas/análisis , Evaluación Preclínica de Medicamentos , Femenino , Enfermedades Fetales/microbiología , Embarazo , Ratas , Infecciones Estafilocócicas/microbiología , Staphylococcus/inmunologíaRESUMEN
After the immunization of pregnant rats with purified adsorbed staphylococcal toxoid the antigen could be detected 2-48 hours later in the parenchymatous organs (the liver, the spleen), but not in the blood serum and the amniotic fluid. The rats immunized at an early period of pregnancy showed the presence of the antigen in their placenta and fetuses, while after the immunization at a late period of pregnancy the antigen could be only seldom detected in the placenta and practically never in the fetuses. There are grounds to believe that staphylococcal toxoid does not pass from the mother to the fetus through the completely formed placenta.
Asunto(s)
Intercambio Materno-Fetal , Toxoide Estafilocócico/administración & dosificación , Animales , Femenino , Inyecciones Subcutáneas , Embarazo , Complicaciones Infecciosas del Embarazo/prevención & control , Ratas , Infecciones Estafilocócicas/prevención & control , Distribución Tisular , VacunaciónRESUMEN
The experiments on gravid rats showed that generalized staphylococcal infection in the female rats resulted in intrauterine infecting of the fetus and had a negative effect on its antenatal development: increased embryonal death rate, decreased weight gain, etc. In case of staphylococcal septicemia the amniotic waters were a peculiar reservoir of the causative agent where it accumulated in larger amounts than in the fetus tissues. Efficiency of oxacillin in daily doses of 144 and 72 mg was shown in treatment of the rat intrauterine infection. High sensitivity of the infected embryons to higher doses of the drug was found.