RESUMEN

BACKGROUND: Since the emergence of diffusion tensor imaging, a lot of work has been done to better understand the properties of diffusion MRI tractography. However, the validation of the reconstructed fiber connections remains problematic in many respects. For example, it is difficult to assess whether a connection is the result of the diffusion coherence contrast itself or the simple result of other uncontrolled parameters like for example: noise, brain geometry and algorithmic characteristics. METHODOLOGY/PRINCIPAL FINDINGS: In this work, we propose a method to estimate the respective contributions of diffusion coherence versus other effects to a tractography result by comparing data sets with and without diffusion coherence contrast. We use this methodology to assign a confidence level to every gray matter to gray matter connection and add this new information directly in the connectivity matrix. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that whereas we can have a strong confidence in mid- and long-range connections obtained by a tractography experiment, it is difficult to distinguish between short connections traced due to diffusion coherence contrast from those produced by chance due to the other uncontrolled factors of the tractography methodology.

Asunto(s)

Encéfalo/diagnóstico por imagen , Imagen de Difusión por Resonancia Magnética/métodos , Vías Nerviosas/diagnóstico por imagen , Encéfalo/anatomía & histología , Encéfalo/fisiología , Mapeo Encefálico/métodos , Humanos , Procesamiento de Imagen Asistido por Computador/métodos , Modelos Biológicos , Vías Nerviosas/anatomía & histología , Vías Nerviosas/fisiología , Radiografía , Sensibilidad y Especificidad

RESUMEN

Many complex systems may be described by not one but a number of complex networks mapped on each other in a multi-layer structure. Because of the interactions and dependencies between these layers, the state of a single layer does not necessarily reflect well the state of the entire system. In this paper we study the robustness of five examples of two-layer complex systems: three real-life data sets in the fields of communication (the Internet), transportation (the European railway system), and biology (the human brain), and two models based on random graphs. In order to cover the whole range of features specific to these systems, we focus on two extreme policies of system's response to failures, no rerouting and full rerouting. Our main finding is that multi-layer systems are much more vulnerable to errors and intentional attacks than they appear from a single layer perspective.

RESUMEN

Understanding the large-scale structural network formed by neurons is a major challenge in system neuroscience. A detailed connectivity map covering the entire brain would therefore be of great value. Based on diffusion MRI, we propose an efficient methodology to generate large, comprehensive and individual white matter connectional datasets of the living or dead, human or animal brain. This non-invasive tool enables us to study the basic and potentially complex network properties of the entire brain. For two human subjects we find that their individual brain networks have an exponential node degree distribution and that their global organization is in the form of a small world.

Asunto(s)

Mapeo Encefálico/métodos , Encéfalo/anatomía & histología , Imagen de Difusión por Resonancia Magnética/métodos , Encéfalo/fisiología , Humanos , Procesamiento de Imagen Asistido por Computador/métodos , Fibras Nerviosas/ultraestructura , Tamaño de los Órganos , Sustancia Gris Periacueductal/anatomía & histología , Sustancia Gris Periacueductal/ultraestructura

RESUMEN

The knowledge of real-life traffic patterns is crucial for a good understanding and analysis of transportation systems. These data are quite rare. In this paper we propose an algorithm for extracting both the real physical topology and the network of traffic flows from timetables of public mass transportation systems. We apply this algorithm to timetables of three large transportation networks. This enables us to make a systematic comparison between three different approaches to construct a graph representation of a transportation network; the resulting graphs are fundamentally different. We also find that the real-life traffic pattern is very heterogenous, in both space and traffic flow intensities, which makes it very difficult to approximate the node load with a number of topological estimators.

RESUMEN

Many complex networks are only a part of larger systems, where a number of coexisting topologies interact and depend on each other. We introduce a layered model to facilitate the description and analysis of such systems. As an example of its application, we study the load distribution in three transportation systems, where the lower layer is the physical infrastructure and the upper layer represents the traffic flows. This layered view allows us to capture the fundamental differences between the real load and commonly used load estimators, which explains why these estimators fail to approximate the real load.