RESUMEN

Protein (m.v. 53 kilodalton) with electrophoretic mobility identical to that of protein detected in leukocytes of patients with Down's syndrome and of protein p53 obtained from mouse ascites carcinoma was demonstrated by polyacrylamide gel electrophoresis in healthy donors' leukocytes cultured with PHA and in peripheral blood of patients with chronic myeloleukemia. Appearance of the class p53 proteins in leukocytes of patients may be connected with the presence in their blood of the population of immature or transformed, proliferating or merely DNA-synthesizing leukocytes, particularly those amplifying the gene that codes protein p53.

Asunto(s)

Proteínas Sanguíneas/análisis , Leucocitos/análisis , Proteínas de Neoplasias/sangre , Fosfoproteínas/sangre , Animales , Carcinoma de Ehrlich/análisis , Síndrome de Down/sangre , Electroforesis en Gel de Poliacrilamida , Humanos , Leucemia Mieloide/sangre , Ratones , Peso Molecular , Proteínas de Neoplasias/análisis , Solubilidad , Espectrofotometría , Proteína p53 Supresora de Tumor