RESUMEN
Silver nanoclusters (AgNCs) have emerged as versatile nanomaterials with immense potential in theranostic applications, combining therapeutic and diagnostic functions in a single platform. This review provides a comprehensive overview of recent advancements in the synthesis, characterization, and utilization of AgNCs for theranostics. The synthesis of AgNCs has witnessed significant progress, with numerous strategies such as chemical reduction, green synthesis, and templated approaches being employed to control size, shape, and stability. Their unique optical properties, including strong fluorescence and surface-enhanced Raman scattering (SERS) signals, make AgNCs ideal candidates for bioimaging and diagnostic purposes. Additionally, the surface chemistry of AgNCs allows for facile functionalization with targeting ligands and therapeutic agents, enhancing their specificity and efficacy. In the realm of diagnostics, AgNCs have been employed for various imaging modalities, including fluorescence imaging, photoacoustic imaging, and SERS-based sensing. Their excellent photostability and biocompatibility make them suitable for in vitro and in vivo imaging applications, enabling the real-time monitoring of disease progression and treatment response.
Asunto(s)
Nanopartículas del Metal , Plata , Plata/química , Nanopartículas del Metal/química , Espectrometría Raman/métodos , Nanomedicina Teranóstica/métodos , Humanos , AnimalesRESUMEN
The present study is aimed to evaluate in vitro thrombolytic activity and antioxidant activity of Hibiscus tiliaceus L. Chemical characterization of bioactive extract was determined by using GC-MS analysis. The thrombolytic potential was performed by the clot lysis method. Antioxidant activity was evaluated by an in vitro assay involving DPPH radical scavenging and hydrogen peroxide scavenging assay. Blood Clots when treated with sterile distilled water, petroleum ether extract, methanol extract and streptokinase showed 7.983 ± 2.197%, 34.10 ± 8.436%, 14.41 ± 5.276 and 62.21 ± 5.519 clot lysis, respectively. Petroleum ether extract shows significant activity when compared with control (P ≤ 0.05). All extracts showed concentration dependent free radical scavenging activity. Bioactive extract of H. tiliaceus contained 23 phytoconstituents as revealed by GC-MS study. The significant thrombolytic activity is exhibited due to presence of sterols as reveled by GC-MS analysis. Further study required to confirm in vivo clot lysis properties.