RESUMEN
Alzheimer's Disease (AD) remains a formidable challenge due to its complex pathology, notably involving mitochondrial dysfunction and dysregulated microRNA (miRNA) signaling. This study delves into the underexplored realm of miRNAs' impact on mitochondrial dynamics and their interplay with amyloid-beta (Aß) aggregation and tau pathology in AD. Addressing identified gaps, our research utilizes advanced molecular techniques and AD models, alongside patient miRNA profiles, to uncover miRNAs pivotal in mitochondrial regulation. We illuminate novel miRNAs influencing mitochondrial dynamics, Aß, and tau, offering insights into their mechanistic roles in AD progression. Our findings not only enhance understanding of AD's molecular underpinnings but also spotlight miRNAs as promising therapeutic targets. By elucidating miRNAs' roles in mitochondrial dysfunction and their interactions with hallmark AD pathologies, our work proposes innovative strategies for AD therapy, aiming to mitigate disease progression through targeted miRNA modulation. This contribution marks a significant step toward novel AD treatments, emphasizing the potential of miRNAs in addressing this complex disease.
Asunto(s)
Enfermedad de Alzheimer , Péptidos beta-Amiloides , MicroARNs , Microglía , Dinámicas Mitocondriales , Enfermedad de Alzheimer/metabolismo , Enfermedad de Alzheimer/genética , MicroARNs/metabolismo , MicroARNs/genética , Humanos , Péptidos beta-Amiloides/metabolismo , Dinámicas Mitocondriales/fisiología , Animales , Microglía/metabolismo , Transducción de Señal/fisiologíaRESUMEN
In this paper,we reviewed the various advanced technologies and methods that could help patients for measuring adherence of patients.There exist intelligent technologies that are available for measuring medication adherence,including medication event monitoring system (MEMS(R)),smart blister packs,radio frequency identification(RFID) embedded smart drawers,and wisely aware RFID dosage (WARD) system.Utilization of these advanced technologies and systems have aided in enhancing the adherence to a greater extent.For example,MEMS(R) refers to the electronic cap that counts the number of bottles opened,but it can be employed only with bottles.Smart blisters are pharmaceutical packagings that possess the capability of monitoring when a pill or tablet is taken out of its packing.All those intelligent technologies can help in active monitoring of patients regarding adherence and capable of eradicating various medication errors due to which adherence is affected.