RESUMEN

The binding of nonsteroidal anti-inflammatory drugs (NSAID), voltaren and piroxicam, to the membranes of erythrocyte ghosts and phosphatidylcholine liposomes was studied by the fluorescent probe method. The drugs were shown to possess high affinity to the both types of the membranes. Voltaren was mainly located in the lipid part of erythrocyte ghost membranes, while piroxicam was uniformly distributed between the protein and lipid components of the membranes. The findings suggest that the differences in the binding characteristics of the studied NSAID might determine to a certain extent the specificity of their anti-inflammatory action.

Asunto(s)

Diclofenaco/farmacocinética , Membrana Eritrocítica/metabolismo , Liposomas/farmacocinética , Piroxicam/farmacocinética , Animales , Colorantes Fluorescentes , Técnicas In Vitro , Lípidos de la Membrana/metabolismo , Proteínas de la Membrana/metabolismo , Fosfatidilcolinas/metabolismo , Unión Proteica/efectos de los fármacos , Ratas