RESUMEN
The influence of Soviet-made antidepressants pyrazidol and incazane on some clonidine-induced effects (hypolocomotion, reactions of synchronization and desynchronization in the EEG, aggression) were studied. Pyrazidol and incazane reduce the effects of low doses of clonidine--the hypolocomotor one and the synchronization reaction in the EEG and enhance the effects of a high dose of clonidine--aggression and the desynchronization reaction in the EEG. The reduction of the sedative effects of clonidine as well as the enhancement of its activating effects by antidepressants can reflect the activation of adrenergic transmission by them. The adrenopositive effect of pyrazidol and incazane is more pronounced that that of imipramine.
Asunto(s)
Antidepresivos/farmacología , Carbazoles/farmacología , Carbolinas/farmacología , Clonidina/farmacología , Agresión/efectos de los fármacos , Animales , Sincronización Cortical/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Interacciones Farmacológicas , Electroencefalografía/efectos de los fármacos , Femenino , Locomoción/efectos de los fármacos , Masculino , Ratones , ConejosRESUMEN
In experiments on unanesthetized rabbits it was found that the effects of ketamine and kalipsol were characterized by a decrease of the negative phase amplitude of the primary response (PR) of evoked potentials (EP) and the secondary positive deviation of EP of the cortical somatosensory region.
Asunto(s)
Potenciales Evocados Somatosensoriales/efectos de los fármacos , Potenciales Evocados Visuales/efectos de los fármacos , Ketamina/farmacología , Anestésicos/farmacología , Animales , Relación Dosis-Respuesta a Droga , Estimulación Eléctrica , Masculino , Estimulación Luminosa , Conejos , Factores de TiempoRESUMEN
The pattern of neuronal responses to alterations in hormonal homeostasis was specified. A study was made of neuronal responses of intact and neuronally isolated strips of the sensorimotor cortex (ISC) to intravenous injection of thyroxine. The neuronal response of the ISC was found to differ substantially from the response of intact cortical neurons. Less percentage of the responding neurons was registered in the ISC. The responses were considerably shortened, while the neurons discharged at a lower frequency. The differences indicate that, as compared to subcortical structures, the cortical neurons are less susceptible to blood hormones. It is emphasized that subcortical structures, particularly the hypothalamus are of major importance for transmission of hormonal influences to the brain cortex.