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Fiziol Zh (1994) ; 54(4): 47-54, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18756775

RESUMEN

Human cord blood cells were shown to produce interferon-alpha- and -gamma in vitro, both spontaneously and following adequate induction. Transplantation of human blood cord cells to mice led to endogenous interferonogenesis activation, serum interferon levels as well as interferon-alpha and interferon-gamma synthesis by activated peripheral blood leucocytes becoming higher. The maximal interferon accumulation in murine blood sera following transplantation did not coincide with interferonogenesis dynamics observed due to the effect of standard early and late interferon inducers - poly I:C and ridostin, respectively. Interferonogenesis activation was accompanied by increased functional activty of phagocytic system cells.


Asunto(s)
Trasplante de Células Madre de Sangre del Cordón Umbilical , Sangre Fetal/citología , Sangre Fetal/inmunología , Interferón-alfa/biosíntesis , Interferón gamma/biosíntesis , Animales , Humanos , Inmunidad Celular , Inductores de Interferón/farmacología , Interferón-alfa/sangre , Interferón gamma/sangre , Ratones , ARN Bicatenario/farmacología , ARN de Hongos/farmacología
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