RESUMEN
Parallel cytological and histological studies were performed for 87 patients with pulmonary adenocarcinoma. Sputum, impression smears of the bronchial mucosa, aspirates from the bronchi, punctates of the tumor obtained transbronchially, pieces of tumor obtained at bronchoscopy, and operation material were examined. Considerable difficulties wre found in cytological diagnosis of adenocarcinomas due to degenerative changes in tumor cells, the presence of cells of the metaplastic columnar epithelium and marked anaplasia of tumor cells in adenocarcinoma with low differentiation. The frequency of diagnostic errors was 20.0--50.6% depending on the histological form of adenocarcinoma and the accompanying processes in bronchi. The cytological criteria improving the differential diagnosis of adenocarcinoma are presented. The validity of cytological diagnosis of adenocarcinoma does not depend on the nature of the material examined.
Asunto(s)
Adenocarcinoma/diagnóstico , Citodiagnóstico/métodos , Neoplasias Pulmonares/diagnóstico , Adenocarcinoma Papilar/diagnóstico , Bronquios/patología , Diagnóstico Diferencial , Humanos , Punciones , Esputo/citologíaRESUMEN
The peculiarities of clinical manifestations of glandular carcinoma of the lung have been studied, an account is taken of histological tumor variants and the degree of tumor proliferation. The results of treatment are analysed in relation to the prognosis of the disease in 305 patients. The peculiar clinical course of lung adenocarcinoma seems to be due to the predominantly peripheral kind of the tumor and relatively prompt lympho-hematogenic metastasization. Marked anaplasia of the tumor revealed morphologically is usually indicative of the dissemination even in insignificant local spread. Satisfactory results of surgical treatment are gained only in early stages (I--II), mainly in patients with high-differentiated adenocarcinoma.