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Experiments were carried out on 32 Nembutal anaesthetized mongrel dogs from both sexes. After 45 min control period unilateral renal ischemia was achieved by clamping the left renal artery for 90 min. In part of the experiments (n = 8) after clamp removal 3 consecutive 45 min periods were performed. The function of the intact right kidney was investigated. Mean arterial pressure (MAP), heart rate (HR), glomerular filtration rate (GFR), urine flow rate (V), fractional excretions of sodium (FENa), potassium (FEK) and chloride (FECl) and plasma levels of atrial natriuretic peptide, dopamine and antidiuretic hormone were evaluated. During ischemia MAP was elevated from 122.5 +/- 3.1 to 140.2 +/- 2.7 mmHg (p < 0.001), HR decreased from 119 +/- 4 to 102.5 +/- 3.9 beats/min (p < 0.01) as compared to the control period. GFR did not change significantly, while all excretory parameters increased: V from 8.7 +/- 1.2 to 14.5 +/- 1.7 microliters/min/gr kidney tissue (p < 0.05); FENa from 2.3 +/- 0.2 to 3.6 +/- 0.3% (p < 0.01); FEK from 40.0 < 3.5 to 51.2 < 2.8% (p < 0.05); FECl from 1.8 < 0.3 to 2.6 < 0.3% (p < 0.05). MAP remained elevated in the first and the second postischemic periods and was paralleled by the sustained increase in FENa and FECl, while FEK remained higher to the end of the experiment. ANP was significantly elevated during ischemia: on 75 min--p < 0.01 and on 105 min.--p < 0.05. AVP and dopamine showed no statistically significant changes during the investigated periods.(ABSTRACT TRUNCATED AT 250 WORDS)

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The authors have examined 161 persons from the production of fodder yeasts. On the background of detailed clinical examination are performed immunoallergological studies, including skin allergologic tests with series of standard allergens and antigens of the produced culture yeasts and determined immunoprecipitants in the blood serum. Increased sensibilization is established in 34.7% of the examined, as the prevailing cases are with monoallergy. More seldom--in 18.8% are established immunoprecipitations with the professional allergens. The changed general and specific immunoallergologic reactivity in part of the workers is due exclusively to the biological factors of the working environment.

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The release of nystatin from monolithic bioerodible system with pectin was studied. The process of both system degradation and drug release was expressed with an equation of Hixon and Crowell. It was established that an increasing thickness of the system as well as an increase of drug concentration decreased the rate of erosion and the release of the active principle. Both the concentration of the plastificator and the temperature of drying the system in the range of investigation did not change these processes.

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Standard skin wounds have been surgically induced in Wistar albino rats. The wounds were covered with 5% unguentum containing fractions C1 and C5, isolated from the flowers of Calendula officinalis belonging to fam. Compositae, in combination with allantoin. Epithelization has been determined in dynamics as a percentage compared with the beginning of the experiment, using the formula (formula: see text), where t is the wound surface in mm2 and n is the respective day after the beginning of the experiment. The wound exudate has been studied cytologically using light- and fluorescent microscopy on the 8th, 24th and 48th hour after inflicting the wounds. The histological changes in biopsy material taken from the edges of the wounds on the 10th day have also been investigated. The drug combination applied markedly stimulates physiological regeneration and epithelialization. This effect is assumed to be due to more intensive metabolism of glycoproteins, nucleoproteins and collagen proteins during the regenerative period in the tissues.

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The variations in the urinary excretion of half-oxidized metabolites, nonprotein nitrogen and chlorides, serum activities of LDH, MDH and ScDH, liver and kidney himogenates and histomorphologic patterns of liver, kidney and muscle tissue were studied in experimental animals, exposed to high-frequency vibrations - 100 hz. with amplitude 0.1 mm, for 60 days. The probable mechanisms of effect of the vibration factor on urinary half-oxidzed metabolite excretion are discussed. These include increased protein and carbohydrate catabolism, disturbances in the oxidoreduction processes, impairement of oxygen tissue supply, impaired urinary metabolite excretion, ect. It is suggested, after additional examination of haman subjects, to include the parameter "total amount of urinary half-oxidized metabolites" in the complex diagnosis of vibration injury in man.

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