Asunto(s)
Nucleótidos de Adenina/metabolismo , Encéfalo/enzimología , Xantinas/farmacología , 5'-Nucleotidasa , Adenosina Desaminasa/metabolismo , Animales , Cafeína/farmacología , Femenino , Cobayas , Hígado/enzimología , Masculino , Nucleotidasas/metabolismo , Purina-Nucleósido Fosforilasa/metabolismo , Ratas , Ratas Endogámicas , Teobromina/farmacología , Teofilina/farmacologíaAsunto(s)
Nucleótidos de Adenina/metabolismo , Adenosina/metabolismo , Encéfalo/metabolismo , Hipoxia Encefálica/metabolismo , Animales , Encéfalo/ultraestructura , Isquemia Encefálica/metabolismo , Isquemia Encefálica/patología , Hipoxia Encefálica/patología , Técnicas In Vitro , Ratas , Ratas EndogámicasAsunto(s)
Prueba de Esfuerzo , Temperatura Cutánea , Adulto , Femenino , Frente , Humanos , Masculino , Muslo , TóraxRESUMEN
Serum copper and ceruloplasmin levels are known to increase in several malignancies such as osteosarcomas, some gastrointestinal tumors, and lung cancer. In this study serum copper and ceruloplasmin levels in 40 patients with primary brain tumors were studied. Both parameters were increased in sera of patients with tumors in comparison with healthy subjects or patients with non-tumorous neurological diseases. It is concluded that copper and ceruloplasmin represent a good complement to some other nonspecific parameters in evaluating the activity of malignancy and the therapeutic results.
Asunto(s)
Neoplasias Encefálicas/sangre , Ceruloplasmina/metabolismo , Cobre/sangre , Adolescente , Adulto , Anciano , Astrocitoma/sangre , Neoplasias Encefálicas/patología , Neoplasias Cerebelosas/sangre , Ependimoma/sangre , Femenino , Glioblastoma/sangre , Humanos , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Oligodendroglioma/sangreRESUMEN
Some pyrimidine analogues--especially 6-azauridine and 5-azacytidine at a final concentration of 1 mmol dm-3--significantly depressed adenosine deaminase activity isolated and purified from bovine heart. Both the above mentioned azapyrimidine nucleosides were effective competitive inhibitors of this enzyme. The inhibitory effect of some clinically used pyrimidine analogues may be of importance for explanation of their mechanisms of action on the cell metabolism.
Asunto(s)
Inhibidores de la Adenosina Desaminasa , Miocardio/enzimología , Nucleósido Desaminasas/antagonistas & inhibidores , Pirimidinas/farmacología , Adenosina/metabolismo , Animales , Bovinos , Técnicas In Vitro , CinéticaRESUMEN
By means of sensitive and specific radiochromatographic methods the activities of adenosine deaminase and purine nucleoside phosphorylase in peripheral blood cells of patients with bronchogenic carcinoma were estimated. It has been shown that purine nucleoside phosphorylase activity was two- to three-fold higher in lymphocytes of patients with epidermoid as well as other types of bronchogenic carcinoma in comparison with a group of healthy individuals. Adenosine deaminase activity in lymphocytes was elevated only in the group of patient with nonepidermoid carcinoma. The authors suggest that especially the estimation of purine phosphorylase activity in lymphocytes would be a useful laboratory test in the study of immune responsiveness of patients with bronchogenic carcinoma.