RESUMEN

An efficient and facile chemoenzymatic synthesis of levamisole by employing lipase-mediated resolution of 3-hydroxy-3-phenylpropanenitrile followed by its conversion to beta-amino alcohol as the key intermediate is described.

Asunto(s)

Levamisol/síntesis química , Lipasa/química , Acetatos/química , Alcoholes/química , Humanos , Nitrilos/química , Relación Estructura-Actividad