RESUMEN
Finoptin in a dose of 0,145 mg/kg prevented cardiomyocytic immune disorders in dogs and rats with cardiogenic shock of immune genesis. In test systems, the drug and nifedipine reduced the immune lysis in the cells by the complement.
Asunto(s)
Bloqueadores de los Canales de Calcio/uso terapéutico , Corazón/efectos de los fármacos , Enfermedades del Sistema Inmune/prevención & control , Choque Cardiogénico/prevención & control , Animales , Proteínas del Sistema Complemento/análisis , Proteínas del Sistema Complemento/efectos de los fármacos , Modelos Animales de Enfermedad , Perros , Evaluación Preclínica de Medicamentos , Femenino , Hemodinámica/efectos de los fármacos , Enfermedades del Sistema Inmune/etiología , Enfermedades del Sistema Inmune/inmunología , Enfermedades del Sistema Inmune/fisiopatología , Masculino , Ratas , Choque Cardiogénico/etiología , Choque Cardiogénico/inmunología , Choque Cardiogénico/fisiopatología , Factores de TiempoRESUMEN
The colony formation in spleen of lethally irradiated syngeneic or hybrid recipients was studied after transplantation of bone marrow cells, with or without macrophages from lymph nodules or from peritoneal cavity of mice, cells of macrophage-like cell line J-774, and monocytes from peripheral blood of healthy donors. The direction of stem cell differentiations in the presence of all the types of mononuclear phagocytes was seen to change from mainly erythroid to mainly myeloid one. The ratio of erythroid to myeloid colonies became equal to 0.5-0.9 instead of 2.0, when bone marrow cells were injected with equivalent quantity of mononuclear phagocytes. This new regulatory function of mononuclear phagocytes is discussed.