RESUMEN
Experiments were performed on Wistar male rats, starting from the 28th month of age. The effect of dietary sorbent (non coated nitrogen-containing carbon administered as 10 day courses at 1 month intervals in dosage of 10 ml/kg) on lifespan and a number of biological indices were studied. Enterosorption resulted in the increase of mean and maximal lifespan by 43 and 34% respectively. Analysis of the effect of enterosorption on activity of microsomal enzymes, intensity of total RNA and protein biosynthesis, lipid metabolism, formation of free radicals etc. showed that it produced a positive influence on the functional state of the studied systems and increased the organism's adaptive capacities. Enterosorption was found to delay the rate of onset of age-related structural changes in the organs and tissues.
Asunto(s)
Carbón Orgánico/farmacología , Longevidad/efectos de los fármacos , Envejecimiento/efectos de los fármacos , Animales , Metabolismo de los Lípidos , Hígado/efectos de los fármacos , Hígado/enzimología , Hígado/ultraestructura , Masculino , Miocardio/citología , Miocardio/ultraestructura , Biosíntesis de Proteínas , ARN/biosíntesis , Ratas , Ratas EndogámicasRESUMEN
The effect of repeated courses of enterosorption upon the mean and maximal lifespan and some functional and metabolic indices was determined in 28-month-old Wistar rats. Significant increase of mean and maximal lifespan of old rats was noted at certain regimens of enterosorption. The experimental animals demonstrated less marked age-related structural and ultrastructural changes in the liver, kidneys, myocardium, intestines, pancreas, as compared with control animals. Enterosorption leads to a reduction of pentobarbital-induced sleep, decrease of content of cytochrome P-450, blood cholesterol and triglycerides, cardiac and cerebral tissue cholesterol, total lipids, liver cholesterol and triglycerides. Enterosorption was found to increase the RNA and protein biosynthesis in the liver, kidneys and adrenals of old animals.
Asunto(s)
Carbón Orgánico/farmacología , Absorción Intestinal , Longevidad/efectos de los fármacos , Envejecimiento , Animales , Encéfalo/metabolismo , Carbón Orgánico/efectos adversos , Sistema Enzimático del Citocromo P-450/metabolismo , Corazón/anatomía & histología , Hemoperfusión , Riñón/anatomía & histología , Metabolismo de los Lípidos , Hígado/anatomía & histología , Hígado/metabolismo , Masculino , Microscopía Electrónica , Miocardio/metabolismo , Ratas , Ratas EndogámicasAsunto(s)
Bronquitis/rehabilitación , Polvo , Hierro , Minería , Enfermedades Profesionales/rehabilitación , HumanosRESUMEN
Age-related features of the peripheral blood (red cell and leukocyte counts, hemoglobin level) and phagocytic activity of peritoneal macrophages were studied in experiments on gnotobiotic and conventional Wistar male rats aged 2, 5, 9 and 35 months. With aging, the conventional Wistar rats showed a significantly lower phagocytic activity in the presence of a progressively increasing leukocyte count as compared with the gnotobiotic animals. The red cell count and hemoglobin level dropped in the conventional species with age, while the gnotobiotic ones manifested no appreciable changes in the indices reviewed.