RESUMEN
Content of ATP and adenylate nucleotides was not markedly altered in rats during a traumatic shock induced by Cannon's procedure involving an impairment of skeletal muscles. Energy potential and content of creatine phosphate were only slightly decreased in these tissues, while the level of lactate and the lactate/pyruvate ratio were increased at the terminal phase.
Asunto(s)
Metabolismo Energético , Músculos/metabolismo , Choque Traumático/metabolismo , Nucleótidos de Adenina/metabolismo , Animales , Masculino , Consumo de Oxígeno , Fosfocreatina/metabolismo , RatasAsunto(s)
Metabolismo Energético , Riñón/metabolismo , Hígado/metabolismo , Choque Traumático/metabolismo , Animales , Masculino , RatasRESUMEN
The guthymine medication of a severe shock in rats started 10-20 minutes after injury is shown to eliminate energy metabolism disorders in the brain, liver and kidneys. In the brain of the guthamyine treated rats even a somewhat reduced adenosinetriphosphate content was demonstrable. Administration of guthymine together with polyglucin to cats in a torpid phase of the shock did not effect treir survival, but shortened the life-span of the test animals as compared to controls (receiving polyglucin alone). With guthymine addid to polyglucin the lactate and pyruvate concentration in the blood remained unchanged.