RESUMEN

A theoretical model of enzymatic reaction is formulated in which the modulation of the reaction coordinates by low-frequency conformational motions of the enzyme molecule causes the lowering of the activation energy barriers until they completely disappear. If the rates of electron transitions in the enzyme-substrate complex exceed the characteristic frequencies of conformational motions then the rate of the elementary enzymatic reaction shows hysteresis dependence on temperature and substrate concentration.

Asunto(s)

Enzimas/metabolismo , Modelos Biológicos , Conformación Proteica , Catálisis , Cinética , Fenómenos Físicos , Física , Termodinámica