RESUMEN
Removal of the pineal gland leads to structural and functional rearrangement of gastric endocrine cells and thyroid C-cells in albino rats, as was shown by immunohistological methods and morphometry. Injection of pineal peptides epithalone and epithalamine eliminated these changes. Biological activity of epithalone is believed to be higher than that of epithalamine.
Asunto(s)
Células APUD/fisiología , Péptidos/fisiología , Glándula Pineal/fisiología , Glándula Tiroides/fisiología , Células APUD/citología , Células APUD/efectos de los fármacos , Animales , Masculino , Oligopéptidos/farmacología , Péptidos/farmacología , Ratas , Ratas Wistar , Glándula Tiroides/citología , Glándula Tiroides/efectos de los fármacosRESUMEN
Experimental investigations on rats have shown that development of dyshormonal immunodepression after ionizing radiation in sublethal doses depends on indirect effect of corticosteroids. Inhibition of steroidogenesis corrects ultrastructural lesions of the thymus after gamma irradiation.
Asunto(s)
Glucocorticoides/antagonistas & inhibidores , Metirapona/farmacología , Timo/efectos de la radiación , Timo/ultraestructura , Animales , Rayos gamma , Masculino , Microscopía Electrónica , Ratas , Ratas Wistar , Timo/metabolismoRESUMEN
Endocrine cells in the stomach of pinealectomized rats after injection of epithalone (pineal gland peptide) were studied by immunohistochemical tests, morphometry, and image analysis microscopic images. A functional relationship was found between the pineal gland and stomach, which is regulated by peptides produced by the pineal gland.