RESUMEN
The data on the relationship between the epizootic process in the population of mice (the source of Hantavirus infection) and the seasonal manifestations of morbidity in hemorrhagic fever with renal syndrome (HFRS) in the southern region of the Russian Far East are presented. The asynchronous course of the epizootic process in the population of rodents causes irregularity in the spread of HFRS in the region and periodicity in the appearance of foci. Seasonal rises in HFRS morbidity coincide with the activity of the epizootic process in the population of mice: spring-summer rises with an increase in the number of infected rodents in the populations of large Japanese field mice and autumn-winter rises in voles.
Asunto(s)
Vectores de Enfermedades , Ecosistema , Fiebre Hemorrágica con Síndrome Renal/epidemiología , Fiebre Hemorrágica con Síndrome Renal/veterinaria , Muridae , Enfermedades de los Roedores/epidemiología , Animales , Antígenos Virales/análisis , Reservorios de Enfermedades/estadística & datos numéricos , Reservorios de Enfermedades/veterinaria , Epítopos , Virus Hantaan/inmunología , Fiebre Hemorrágica con Síndrome Renal/inmunología , Humanos , Prevalencia , Estudios Retrospectivos , Enfermedades de los Roedores/inmunología , Estaciones del Año , Estudios Seroepidemiológicos , Siberia/epidemiologíaRESUMEN
The employment of two serological tests (indirect fluorescence antibody technique and neutralization test) demonstrated the leading role of Hantaan virus serotype 1 strains isolated from field mice in the pattern of the incidence of hemorrhagic fever with renal syndrome (HFRS). Proofs of the etiological importance of strains of serotypes 3 and 5 occurring in brown rats and Cl. rufocanus were obtained. No data on any association of human HFRS cases with strains of serotype 4 isolated from reed voles could be demonstrated.
Asunto(s)
Fiebre Hemorrágica con Síndrome Renal/etiología , Orthohantavirus , Animales , Anticuerpos Antivirales/sangre , Especificidad de Anticuerpos/inmunología , Orthohantavirus/clasificación , Orthohantavirus/inmunología , Orthohantavirus/aislamiento & purificación , Fiebre Hemorrágica con Síndrome Renal/epidemiología , Fiebre Hemorrágica con Síndrome Renal/inmunología , Fiebre Hemorrágica con Síndrome Renal/microbiología , Humanos , Roedores/microbiología , Estudios Seroepidemiológicos , Serotipificación , Siberia/epidemiologíaAsunto(s)
Brotes de Enfermedades/veterinaria , Vectores de Enfermedades , Fiebre Hemorrágica con Síndrome Renal/veterinaria , Orthohantavirus/inmunología , Enfermedades de los Roedores/inmunología , Roedores/inmunología , Animales , Anticuerpos Antivirales/análisis , Antígenos Virales/análisis , Epítopos/análisis , Fiebre Hemorrágica con Síndrome Renal/epidemiología , Fiebre Hemorrágica con Síndrome Renal/inmunología , Enfermedades de los Roedores/epidemiología , Estaciones del Año , Siberia/epidemiologíaRESUMEN
The use of the serological method (the indirect fluorescent antibody test) for the examination of 255 persons coming in contact with patients having hemorrhagic fever with the renal syndrome (HFRS) in the foci of this infection where outbreaks of group infection had been registered made it possible to detect mild, unclear and asymptomatic forms of HFRS in 17.7-20.9% of cases. The simultaneous titration of 317 serum samples with two antigens revealed that HFRS virus of serotype 1, similar to strain Hantaan from Korea, may cause, besides the classical forms of the disease, the development of mild and asymptomatic forms of this infection.
Asunto(s)
Fiebre Hemorrágica con Síndrome Renal/diagnóstico , Animales , Técnica del Anticuerpo Fluorescente , Fiebre Hemorrágica con Síndrome Renal/epidemiología , Humanos , Ratones , MuridaeRESUMEN
Examinations of 6362 small mammals of 18 species revealed the main reservoirs of the causative agent of hemorrhagic fever with the renal syndrome (HFRS) in foci of the Primorsky Krai, and demonstrated the importance of individual species in the epidemiology of the infection. Data on the circulation in the region of antigenically different serotypes of HFRS virus are presented.
Asunto(s)
Reservorios de Enfermedades , Vectores de Enfermedades , Fiebre Hemorrágica con Síndrome Renal/transmisión , Animales , Antígenos Virales/análisis , Epítopos/análisis , Orthohantavirus/inmunología , Fiebre Hemorrágica con Síndrome Renal/inmunología , Roedores/inmunología , Estaciones del Año , SiberiaRESUMEN
The sporadic character of the occurrence of hemorrhagic fever with the renal syndrome in the Primorye Territory has been established. Three rodent species have been found to be spontaneously infected with the causative agent of this disease. Antibodies in patients with this disease are detected at its early stages and persist for a long time after convalescence. The possibility of the formation of a contingent immune to hemorrhagic fever, due to the persons who have had mild and asymptomatic forms of this infection has been shown.