RESUMEN
The analysis included 53 patients (32 men and 21 women) aged 43 to 66 years, who were subjected to radical treatment (surgical or combined) because of stomach (22 patients) or large bowel (31 patients) cancer. All the patients were included in the same model of control examinations, which considered evaluation of the erythrocytes TAS and of the Ca19-9, CEA and AFP concentrations in serum. It was confirmed that in all the patients in whom the recurrence and/or the dissemination occurred of the cancer, the average erythrocytes TAS value increased 5.5 times by comparison with the period before progression and 7 times in comparison with the patients without recurrence and/or dissemination of the cancer. Moreover it was shown that statistically significantly higher TAS values were associated with the progression of the large bowel cancer in comparison with the stomach cancer and that the blood cells TAS positively correlated with the changes of the Ca19-9, CEA and AFP concentrations in patients with progression of the cancer after radical treatment.
Asunto(s)
Antioxidantes/metabolismo , Neoplasias del Colon/sangre , Neoplasias del Colon/cirugía , Neoplasias Gástricas/sangre , Neoplasias Gástricas/cirugía , Adulto , Anciano , Progresión de la Enfermedad , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The analysis included 78 patients (42 men and 36 women) aged 48 to 67 years treated with cytostatics because of a neoplastic disease. In all the patients examined was evaluated the influence of the chemotherapy carried out on the glutathione peroxidase (GPx) and glutathione reductase (GR) activities. It was confirmed that the effect of the action on the glutathione enzymes (GE) activity of the antineoplastic chemotherapy changes depending on the duration of the treatment with cytostatics. In the end this activity settles at a high level, statistically significantly higher than that registered before the beginning of the antineoplastic treatment. The increase of the GE activity is mainly favoured by the chemotherapy following the schemes FAC (5-fluorouracyl + doxorubicin + endoxan) and PAC (cisplatin + cyclofosfamide + pharmorubicin).
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Glutatión Peroxidasa/sangre , Glutatión Reductasa/sangre , Glutatión/metabolismo , Anciano , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Acid phosphatase (AcP), beta-glucuronidase (GR) and N-acetyl-beta-D-glucosaminidase (NAG) activity was determined, using semiquantitative cytochemical methods, in the peritoneal fluid lymphocytes obtained from 50 patients with terminal renal failure treated by intermittent peritoneal dialysis. The control group included 30 subjects with normal renal function. The percentage of AcP and NAG-positive lymphocytes was significantly lower and that of the GR-positive cells significantly higher in dialysed patients than in the control group. A group of 22 dialysed patients with bacterial peritonitis showed a significant increase of the percentage of NAG-positive lymphocytes as compared with both the subjects in the control group and the peritonitis-free dialysed ones. Changes of the lymphocytes enzymatic activities were distinct in cells exhibiting the granular reaction type, and to a much lesser extent in those showing granular diffuse reaction.
Asunto(s)
Fallo Renal Crónico/enzimología , Linfocitos/enzimología , Lisosomas/enzimología , Diálisis Peritoneal , Acetilglucosaminidasa/análisis , Fosfatasa Ácida/análisis , Adolescente , Adulto , Infecciones Bacterianas/enzimología , Infecciones Bacterianas/terapia , Femenino , Glucuronidasa/análisis , Humanos , Fallo Renal Crónico/complicaciones , Fallo Renal Crónico/terapia , Masculino , Persona de Mediana Edad , Cavidad Peritoneal/citología , Peritonitis/enzimología , Peritonitis/terapiaAsunto(s)
Ácido Gástrico/metabolismo , Mucosa Gástrica/efectos de los fármacos , Prostaglandinas Sintéticas/uso terapéutico , Úlcera Gástrica/tratamiento farmacológico , Adulto , Anciano , Ensayos Clínicos como Asunto , Epoprostenol/uso terapéutico , Femenino , Mucosa Gástrica/metabolismo , Gastroscopía , Humanos , Masculino , Persona de Mediana Edad , Úlcera Gástrica/fisiopatología , Cicatrización de Heridas/efectos de los fármacosRESUMEN
A double-blind study on prostacyclin (5 ng/kg/min infused i.v. for 5 hrs per day during 6 consecutive days) for the treatment of peptic gastric ulcers was carried out in thirty patients (15 prostacyclin, 15 placebo). Gastroscopy and its scoring was performed 1-2 days before the treatment, as well as a day and a week after the course of treatment was completed. Basal acid output (BAO) and pentagastrin stimulated release of gastric acid (maximum acid output MAO; peak acid output PAO) were measured before the treatment, during the third infusion, and one day after all the infusions had been completed. At the same time the basal release of bicarbonate into gastric juice was determined. Prostacyclin significantly accelerated healing of the ulcers at the end point of the study. Simultaneously, in the prostacyclin-treated patients an increase in bicarbonate release into gastric juice was noted, although the acidity of gastric juice was not changed. Our study shows a cytoprotective action of prostacyclin on a damaged human gastric mucosa.