RESUMEN

Optogenetics is a modern nanobiological approaches allowing modulation of the physiological status of electrostimulated cells, including the neurons. The optogenetic approach was used to evaluate the efficiency of synaptic transmission between the neurons in a mixed corticostriatal culture. Synaptic contacts between the cortical and striatal neurons forming in a mixed culture could be modulated by the opticogenetic methods. Studies of the synaptic interactions between the neurons were essential for understanding the disease mechanisms, and therefore, this method seemed to be promising for biomedical studies.

Asunto(s)

RESUMEN

Huntington's disease (HD) is an inherited autosomal dominant neurodegenerative disorder caused by a polyQ expansion (>36 glutamine repeats) in Huntingtin (Htt) protein. It is believed that dysfunction of corticostriatal system is one of the main pathological events. Special attention is paid to synaptic dysfunction of transmission between cortical and striatal neurons. This review focuses on modern concepts of molecular and cellular mechanisms of HD pathology and especially on alterations in corticostriatal connectivity. Calcium hypothesis of HD and new pharmacological targets are described.

Asunto(s)

RESUMEN

Secondary immunodeficiency was detected in women who gave birth to small-for-date newborns. This state was one of the causes of periodontal and hard dental tissue involvement. Women with small-for-date fetuses are at risk of dental diseases.

Asunto(s)

RESUMEN

Mathematical analysis of heart rhythm helps detect disorders in the adaptation and compensatory potential of the body patients with diseases of the periodontium which are associated with a high stress and overstrain leading to exhaustion of the regulatory mechanisms. This should be borne in mind when planning treatment of such patients.

Asunto(s)

Asunto(s)

RESUMEN

Electroencephalographic studies and mathematical analysis of heart rhythm have shown that reconstructive plastic surgery is a more sparing and physiologic method as against supravaginal amputation of the uterus, providing normal functioning of all the body systems in late periods after surgery.

Asunto(s)

RESUMEN

A deficiency of mineral components in the breast milk and saliva and shifts in the protein, carbohydrate, and lipid metabolism are observed in puerperae with a history of late gestosis; this fact tells negatively on the maxillodental system of the mother and her baby.

Asunto(s)

RESUMEN

Effects of an intrauterine streptococcal infection induced at different stages of pregnancy on the developing fetus and newborn were studied in non-inbred white rats. The course of denture development was found changed in both fetuses and newborns. A number of functional shifts in the central nervous system and physical status, presenting in the postnatal period, were detected in the experimental animals.

Asunto(s)

RESUMEN

Hydrotubation treatment of uterine tube impotency of an inflammatory origin results in many cases in stubborn hemodynamic disorders in the small pelvis organs, that may be normalized after exposure to a permanent magnetic field (magnetophores). Multiple-modality treatment results in recovery of the uterine tube patency in 50% of cases and in pregnancy coming within a year in 22.6% of cases.

Asunto(s)

Asunto(s)

RESUMEN

Blood laser action (red spectrum, a wavelength of 628 nm, pulsed periodic quasi-continuous duty), a noninvasive tool, was demonstrated to stimulate the immune forces of the body, which showed a 2-fold or more decrease in the incidence of inflammatory complications after cesarean operation.

Asunto(s)

Asunto(s)

Asunto(s)

RESUMEN

The preventive antiarrhythmic effect of a new derivative of selenium-containing aralkyl amines, i. e. selenofen-24, was compared with the routinely used drugs-novocainamide, isoptin and inderal. With respect to the preventive effect and spectrum of action selenofen-24 was shown to be advantageous on various experimental models of arrhythmias: aconitine, strophanthin, pituitrin or calcium chloride.

Asunto(s)

Asunto(s)

RESUMEN

It has been demonstrated in an experimental calcium chloride model that piperidine-ethyl-selenophen belonging to the class of selenium derivatives is superior to isoptin in antiarrhythmic action. The drug shortens the duration of arrhythmia and reduces 2-3 times the time required for the recovery of heart rhythm, thereby raising the efficacy of therapy.

Asunto(s)

Asunto(s)

Asunto(s)

RESUMEN

Ampicillin administration during pregnancy exerted no toxic effect on the developing fetus. However, it decreased the body weight of the progeny and the weight of the placenta. Oxacillin had an adverse effect on the pregnancy, labor, fetus and newborn. It is inferred that ampicillin can be used for treatment purposes at any time of the pregnancy whilst oxacillin administration might involve a high risk for the mother, fetus and newborn.

Asunto(s)

Asunto(s)