Asunto(s)
Alginatos/uso terapéutico , Protectores contra Radiación/uso terapéutico , Radioisótopos de Estroncio , Animales , Sistema Digestivo/efectos de los fármacos , Sistema Digestivo/efectos de la radiación , Relación Dosis-Respuesta a Droga , Combinación de Medicamentos , Evaluación Preclínica de Medicamentos , Ácido Glucurónico , Ácidos Hexurónicos/uso terapéutico , Peso Molecular , Ratas , Ratas Endogámicas , Desintoxicación por Sorción/métodosRESUMEN
Calcitonin structure, biological activity, formation in organism and methods of production including isolation from natural sources, chemical synthesis and genetic engineering methods are reviewed.
Asunto(s)
Calcitonina/biosíntesis , Secuencia de Aminoácidos , Animales , Calcitonina/síntesis química , Calcitonina/aislamiento & purificación , Humanos , Datos de Secuencia Molecular , Proteínas Recombinantes/biosíntesis , Proteínas Recombinantes/síntesis química , Proteínas Recombinantes/aislamiento & purificaciónAsunto(s)
Corteza Suprarrenal/fisiología , Timosina/fisiología , Animales , Corticosterona/sangre , Femenino , Masculino , Ratones , Ratones Endogámicos DBA , TimectomíaRESUMEN
Calcitonin effect on lymphoid cells of the marrow, thymus, spleen and lymphoid nodes was studied on guinea-pigs and CBA mice. Calcitonin increased ThyI+ cell number in the marrow and thymus, restored rosette-forming ability of the thymus lymphocytes, heated at 45 degrees C within 1 hour, inducing an appearance of heteroerythrocyte receptors on their surface. The data obtained allow a conclusion that calcitonin is a substance, influencing the lymphoid tissue cell differentiation.
Asunto(s)
Calcitonina/farmacología , Tejido Linfoide/citología , Animales , Células de la Médula Ósea , Diferenciación Celular/efectos de los fármacos , Cobayas , Hormonas/farmacología , Técnicas In Vitro , Recuento de Leucocitos , Ganglios Linfáticos/citología , Ratones , Bazo/citología , Timo/citologíaRESUMEN
It has been shown that thymosin promotes the growth of exocolonies both in the allogeneic and syngeneic systems provided the donor's bone marrow cells were incubated preliminarily in thymosin solution. It is assumed that not only thymocytes but also the humoral factor of the thymus play an important role in colony formation.
Asunto(s)
Trasplante de Médula Ósea , Rechazo de Injerto/efectos de los fármacos , Bazo/inmunología , Timosina/farmacología , Hormonas del Timo/farmacología , Animales , Ensayo de Unidades Formadoras de Colonias , Hibridación Genética , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos CBA , Trasplante Homólogo , Trasplante IsogénicoRESUMEN
The activity of thymosin obtained from calf thymus was examined in the tests in vitro: the reaction of spontaneous rosette formation, blasttransformation reaction to PHA and the reaction of leucocyte migration inhibition. It was demonstrated that the activity which stimulates T-lymphocytes would appear only in cases where donor lymphocytes show depletion in terms of rosette formation and blasttransformation. In some patients thymosin was found to produce the in vitro activation of cell anti-tumor immunity.
Asunto(s)
Linfocitos T/efectos de los fármacos , Timosina/farmacología , Hormonas del Timo/farmacología , Inhibición de Migración Celular , Humanos , Activación de Linfocitos , Fitohemaglutininas/farmacología , Formación de Roseta , Linfocitos T/inmunologíaRESUMEN
Studies have been made on 11-oxycorticosteroid content of the blood serum in spawning salmons. During sexual maturation and spawning migration, the level of 11-oxycorticosteroids in the blood serum undergoes significant changes. The pattern of these changes is similar in both of the species investigated. During fresh-water period of migration, 11-3xycorticosteroid content in the blood serum of females of O. gorbuscha is 3 times higher as compared to that during sea-water period. In O. keta, this level increases two-fold. The increased content of 11-oxycorticosteroids remains constant up to spawning. After the latter, the level of 11-oxycorticosteroids decreases reaching the values typical for sea-water period.