RESUMEN

Cytokines involved in inflammatory and immune response have been associated with risk for development of basal cell carcinoma (BCC). In this study, three functional DNA polymorphisms affecting gene expression were investigated in 54 BCC patients and 111 healthy controls: interleukin-1b (IL-1b) +3953C/T, interleukin-10 (IL-10) - 1082G/A and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms. Significant increase of the variant alleles was observed in IL-10 - 1082G (P = 0.019) and in ACE D (P = 0.003) in BCC patients in comparison to controls. Multivariate logistic regression models evaluated the contribution of homozygous and heterozygous variant polymorphisms to the risk for BCC development. The studied polymorphisms influencing the expression of IL-10 and ACE genes were recognized as potential predictive factors for BCC. These findings suggest a possible molecular mechanism leading to BCC development that is likely to involve the activation of angiotensin receptors in combination with increased plasma levels of IL-10 in patients.

Asunto(s)

Biomarcadores de Tumor/genética , Carcinoma Basocelular/genética , Interleucina-10/genética , Peptidil-Dipeptidasa A/genética , Neoplasias Cutáneas/genética , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Alelos , Angiotensinas/metabolismo , Biomarcadores de Tumor/sangre , Carcinoma Basocelular/sangre , Carcinoma Basocelular/diagnóstico , Estudios de Casos y Controles , Femenino , Regulación Neoplásica de la Expresión Génica , Predisposición Genética a la Enfermedad , Voluntarios Sanos , Humanos , Interleucina-10/sangre , Interleucina-10/metabolismo , Masculino , Persona de Mediana Edad , Peptidil-Dipeptidasa A/metabolismo , Polimorfismo de Nucleótido Simple , Transducción de Señal/genética , Neoplasias Cutáneas/sangre , Neoplasias Cutáneas/diagnóstico , Adulto Joven