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South Med J ; 85(3): 270-3, 1992 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-1546351

RESUMEN

Thirty-nine postmenopausal women were randomized to treatment with either percutaneous estradiol or a placebo. Those taking the estradiol had an increase in serum estradiol to follicular phase levels and a concomitant fall in serum follicle-stimulating hormone (FSH) levels. Atrophic vaginal epithelium became well estrogenized, and the frequency and severity of hot flushes decreased significantly. No significant benefits accrued to those using the placebo. Side effects were mild and similar in both groups. Percutaneous estradiol delivered in an alcohol-water gel is effective in treating climacteric symptoms and is an attractive alternative to both oral and transdermal patch administration of estrogen.


Asunto(s)
Estradiol/administración & dosificación , Menopausia/efectos de los fármacos , Administración Tópica , Método Doble Ciego , Estradiol/efectos adversos , Estradiol/sangre , Femenino , Hormona Folículo Estimulante/sangre , Geles , Humanos , Menopausia/sangre , Seguridad
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