RESUMEN

6 year molecular-biological monitoring of enteroviruses in the Far East and Zabaikalye was carried out. Nucleotide sequence of 125 strains was determined from 2006 to 2011. Molecular analysis was carried out in VP1 virus genome region. Phylogenetic interactions for ECHO-6, ECHO-30, ECHO-11, Coxsackie B-5 (CB-5), Coxsackie B-1 (CB-1) and Coxsackie A-9 (CA-9) were analyzed. Highly dynamic epidemiology was shown to be inherent for ECHO-6 and ECHO-30 viruses and is characterized by genetic heterogeneity and consequent change of virus variants. On the contrary a relative stability of circulating genotypes is intrinsic for CB-1, CB-5 and ECHO-11 enteroviruses. The results of molecular-biological studies indicate frequent introduction of new enterovirus variants from countries of Europe and Asia.

Asunto(s)

Infecciones por Enterovirus/epidemiología , Infecciones por Enterovirus/genética , Enterovirus/genética , Monitoreo Epidemiológico , Epidemiología Molecular , Infecciones por Enterovirus/transmisión , Femenino , Genotipo , Humanos , Masculino , Siberia/epidemiología

RESUMEN

Human papilloma viruses (HPV) of high carcinogenesis risk play important role in development of cancer of oropharyngeal and anogenital areas. Possible malignant transformation of cells, infected by HPV, is due to the expression of three proteins, E6, E7 and E5. These proteins mostly influence on mechanisms that regulate cellular cycle, proliferation and apoptosis inducing and maintaining oncogenesis. This review briefly presents data on malignant tumors induced by HPV as well as biology of these viruses and their vital cycle. Special accent is made on description of current trends in molecular basis of oncogenesis, induced by HPV, which understanding is necessary for elaboration of new methods of treatment for HPV-infection such as therapeutic vaccines.

Asunto(s)

Alphapapillomavirus/patogenicidad , Transformación Celular Neoplásica , Neoplasias/metabolismo , Neoplasias/virología , Proteínas Oncogénicas Virales/metabolismo , Infecciones por Papillomavirus/complicaciones , Neoplasias del Ano/metabolismo , Neoplasias del Ano/virología , Apoptosis/genética , Ciclo Celular/genética , Proliferación Celular , Transformación Celular Neoplásica/genética , Transformación Celular Neoplásica/metabolismo , Epigénesis Genética , Femenino , Regulación Neoplásica de la Expresión Génica , Regulación Viral de la Expresión Génica , Neoplasias de los Genitales Femeninos/metabolismo , Neoplasias de los Genitales Femeninos/virología , Neoplasias de los Genitales Masculinos/metabolismo , Neoplasias de los Genitales Masculinos/virología , Genoma Viral , Inestabilidad Genómica , Humanos , Masculino , Ciclo Menstrual , Mutación , Neoplasias/genética , Proteínas Oncogénicas Virales/genética , Neoplasias Orofaríngeas/metabolismo , Neoplasias Orofaríngeas/virología , Proteínas E7 de Papillomavirus/metabolismo , Infecciones por Papillomavirus/metabolismo , Proteínas Represoras/metabolismo