RESUMEN
Acute alcohol intoxication (AAI, 2.5 g/kg intraperitoneally) was found to be followed by ATP level increase in all brain regions under study. As a result, creatinine kinase and ATPase activities were decreased. Following administration of lithium carbonate (80 mg/kg intragastrically) and ethanol, the content of ATP was increased in the thalamus and cerebellum regions while ATPase activity and non-organic phosphorus level were decreased. Under this condition creatinine kinase activity in the brain cortex as well as in the cerebellum increased as compared to AAI group of animals.
Asunto(s)
Disuasivos de Alcohol/farmacología , Encéfalo/efectos de los fármacos , Metabolismo Energético/efectos de los fármacos , Etanol/farmacología , Litio/farmacología , Intoxicación Alcohólica/metabolismo , Animales , Encéfalo/metabolismo , Interacciones Farmacológicas , Metabolismo Energético/fisiología , Carbonato de Litio , Masculino , RatasRESUMEN
Cytochrome C (a single dose range of 1-200 mg/kg, intraperitoneally) does not possess the antihypoxic activity (altitude chamber, methemoglobinemia, circulatory hypoxia), decreases (in a dose of 50 mg/kg) diuresis in rats modifying diversely (depending on the dose used) the hypnotic effects of general anesthetics and the convulsant activity of corazol and arecoline.
Asunto(s)
Grupo Citocromo c/farmacología , Animales , Isquemia Encefálica/tratamiento farmacológico , Grupo Citocromo c/uso terapéutico , Diuresis/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Evaluación Preclínica de Medicamentos , Interacciones Farmacológicas , Hipoxia/tratamiento farmacológico , Ratones , Ratas , Convulsiones/inducido químicamente , Convulsiones/tratamiento farmacológico , Sueño/efectos de los fármacosRESUMEN
The effect of calcium 4'-phosphopantothenate (CPP) on acute toxicity of streptomycin and the decrease by the antibiotic of the muscle working capacity, "holes" reflex, body temperature and oxygen intake was studied on 258 albino mice weighing 22-26 g. Medical calcium pantothenate (CPA) was used for control purposes. CPP is an antagonist of streptomycin sulfate. In a dose of 1/10 or 1/5 of the LD50 injected intraperitoneally CPP lowered acute toxicity of streptomycin and prevented its effect in a dose of 0.11--1.1 g/kg injected subcutaneously on the muscle working capacity, "holes" reflex and body temperature. The spectrum index of the CPP antitoxic effect was equal to 22.5. By its acute toxicity CPP (LD50 1.18 +/- 0.07 g/kg) did not differ from CPA (LD50 1.25 +/- 0.08 g/kg). The efficacy of CPP, by its antitoxic spectrum, was 1.8 times higher than that of CPA. CPA lowered the streptomycin effect on the "holes" reflex and body temperature, while CPP prevented it. Both the drugs did not influence the decrease in the oxygen consumption induced by streptomycin.
Asunto(s)
Ácido Pantoténico/análogos & derivados , Estreptomicina/antagonistas & inhibidores , Enfermedad Aguda , Animales , Temperatura Corporal/efectos de los fármacos , Femenino , Masculino , Ratones , Músculos/efectos de los fármacos , Orientación/efectos de los fármacos , Consumo de Oxígeno/efectos de los fármacos , Ácido Pantoténico/farmacología , Ácido Pantoténico/uso terapéutico , Reflejo/efectos de los fármacos , Estreptomicina/envenenamientoAsunto(s)
Cafeína/farmacología , Receptores Adrenérgicos/efectos de los fármacos , Receptores Dopaminérgicos/efectos de los fármacos , Anfetamina/farmacología , Animales , Disulfiram/farmacología , Haloperidol/farmacología , Humanos , Ratones , Actividad Motora/efectos de los fármacos , Orientación/efectos de los fármacos , Ratas , Conducta Estereotipada/efectos de los fármacosAsunto(s)
Disulfiram/farmacología , Acetaldehído/metabolismo , Oxidorreductasas de Alcohol/metabolismo , Aldehído Oxidorreductasas/metabolismo , Animales , Biotransformación , Catecolaminas/biosíntesis , Catecolaminas/metabolismo , Gatos , Disulfiram/metabolismo , Ditiocarba/metabolismo , Ditiocarba/farmacología , Perros , Dopamina beta-Hidroxilasa/metabolismo , Etanol/metabolismo , Humanos , Técnicas In Vitro , Ratones , Conejos , Ratas , Serotonina/metabolismo , Tirosina 3-Monooxigenasa/metabolismo , Xantina Oxidasa/metabolismoRESUMEN
The TMTD does not change the secretory activity of the dogs' stomach with its one-time administration by mouth in doses of 0.5--10 mg/kg. With its multiple introduction (10 mg per kg once a day for a space of consecutive 30 days) the secretion of juice increases, while the pepsin content in the juice of dags diminishes. The DEDCS, EEDMDCA, TMTD and EBDCC (singly into the stomach in a dose of 1l5LD50 per kg) bring down the glycogen-forming and secretory function of the liver in rats and inhibit the propulsive activity of the intestines in mice, stimulated with 5-oxytryptophan. The mechanism of the intestinal motor activity inhibition is caused by the inhibition of oxytryptophandecarboxylase (CP 4.1.1.28) in the intestines of the animals with the DTCA derivatives.