RESUMEN
The time course of structural and functional parameters using echocardiography and the level of atrial natriuretic factor (ANF) employing immunoradiometric assay were examined in 37 patients with essential hypertension taking a 3-week therapy with nifedipine (corinfar) in doses individually chosen. The changes in the structural and functional parameters of the hypertensive heart were found to be associated with its endocrine function. A course therapy of patients with essential hypertension with nifedipine in individually based doses caused a significant rise in plasma ANF levels, a normalization of cardiac compensatory mechanism function. The findings may be a basis for studying the new mechanisms of calcium antagonist action.
Asunto(s)
Factor Natriurético Atrial/sangre , Corazón/efectos de los fármacos , Hipertensión/tratamiento farmacológico , Nifedipino/uso terapéutico , Adulto , Anciano , Ecocardiografía , Femenino , Corazón/fisiopatología , Humanos , Hipertensión/fisiopatología , Masculino , Persona de Mediana Edad , Nifedipino/farmacologíaRESUMEN
Changes in parameters for cardiac filling and pump functions during graded exercise were studied in 29 hypertensive patients with various left ventricular myocardial mass and 30 healthy subjects by unidirectional echocardiography. The volume of early diastolic filling decreased and that of diastasis and atrial systole increased with increasing left ventricular mass. These changes were found during graded exercises rather than at rest.
Asunto(s)
Cardiomegalia/fisiopatología , Diástole , Prueba de Esfuerzo , Corazón/fisiopatología , Hipertensión/fisiopatología , Contracción Miocárdica , Cardiomegalia/etiología , Cardiomegalia/patología , Ecocardiografía , Ventrículos Cardíacos , Humanos , Hipertensión/patología , Masculino , Persona de Mediana EdadRESUMEN
As many as 32 patients with moderate arterial hypertension were examined. According to unidimensional echocardiography, the improvement of early diastolic filling of the hypertrophied left ventricle of the heart was recorded during 4 weeks of the treatment with nifedipine, a dihydropyridine blocker of calcium channels. The favourable effect on diastolic filling function was combined with an efficient control over arterial pressure which was determined by a decrease in the systemic vascular resistance. Nifedipine did not produce any depression of contractile and pump functions of the heart.
Asunto(s)
Ecocardiografía , Hipertensión/tratamiento farmacológico , Nifedipino/uso terapéutico , Adulto , Cardiomegalia/diagnóstico , Cardiomegalia/tratamiento farmacológico , Cardiomegalia/fisiopatología , Evaluación de Medicamentos , Corazón/efectos de los fármacos , Corazón/fisiopatología , Hemodinámica/efectos de los fármacos , Hemodinámica/fisiología , Humanos , Hipertensión/diagnóstico , Hipertensión/fisiopatología , Masculino , Persona de Mediana EdadAsunto(s)
Presión Sanguínea/efectos de los fármacos , Corazón/efectos de los fármacos , Hipertensión/tratamiento farmacológico , Nifedipino/uso terapéutico , Adulto , Enfermedad Crónica , Diástole/efectos de los fármacos , Evaluación de Medicamentos , Corazón/fisiopatología , Humanos , Hipertensión/fisiopatología , Masculino , Persona de Mediana EdadRESUMEN
Sympatho-adrenal activity (SAA) was assessed in 67 male patients with essential hypertension and 20 normal subjects. The patients were divided into 2 groups: those with increased (group 1) and normal (group 2) basal SAA. Hyperreactive and normally reactive patients were identified on the basis of plasma norepinephrine elevation in response to one-hour walking in both groups. Therapy with nifedipine alone for 3 weeks was ineffective in hyperreactive first-group patients. The efficiency of nifedipine treatment for essential hypertension may be dependent on baseline sympatho-adrenal activity and reactivity.