RESUMEN
Nine new chromone analogs (1-9) were isolated from the soil actinomycete Microbispora sp. TBRC6027. The chemical structures were determined based upon NMR spectroscopic methods. These compounds were evaluated in vitro by using P19-derived neurons for neuroprotective activity against oxidative stress induced by serum deprivation and showed % viability of neurons at the concentration of 1 ng/mL varied from 43.51% to 52.99% without significant neurotoxicity for P19-derived neurons at the same concentration. Moreover, all tested compounds were inactive for antibacterial activity against both Gram-positive and Gram-negative bacteria and for cytotoxicity against MCF-7 (human breast cancer) and Vero cells at maximum tested concentration 50 µg/mL. However, compounds 4, 6, and 7 displayed weak cytotoxicity against NCI-H187 (human small-cell lung cancer) cells with IC50 in a range of 87.99-91.57 µM.
Asunto(s)
Actinobacteria , Cromonas/farmacología , Fármacos Neuroprotectores/farmacología , Actinobacteria/química , Animales , Antibacterianos/farmacología , Línea Celular Tumoral , Chlorocebus aethiops , Cromonas/aislamiento & purificación , Bacterias Gramnegativas , Bacterias Grampositivas , Humanos , Fármacos Neuroprotectores/aislamiento & purificación , Suelo , Células VeroRESUMEN
Derivatives of the fungal depsidone, nidulin, have been synthesized in order to evaluate the potential of the chemical skeleton as antibacterial agents. Alkylation, acylation, and arylation reactions of nornidulin underwent in a regioselective manner to predominantly produce 8-O-substituted derivatives. Many of the semisynthetic derivatives showed more potent antibacterial activities than nidulin, In particular, 8-O-aryl ether derivatives displayed significant activities against Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus.
Asunto(s)
Antibacterianos/síntesis química , Bacterias Grampositivas/efectos de los fármacos , Animales , Antibacterianos/química , Antibacterianos/toxicidad , Supervivencia Celular/efectos de los fármacos , Chlorocebus aethiops , Dibenzoxepinas/síntesis química , Dibenzoxepinas/química , Dibenzoxepinas/toxicidad , Fibroblastos/efectos de los fármacos , Estructura Molecular , Células VeroRESUMEN
Two salicylaldehyde derivatives (1 and 2), a hydroxymethylphenol (3), five dihydroisobenzofuran (4-8) derivatives, and a 5-chloro-3-deoxyisoochracinic acid (9), together with a known 3-deoxyisoochracinic acid (10) were isolated from the marine fungus Zopfiella marina BCC 18240 (or NBRC 30420). The structures of these compounds were elucidated by extensive spectroscopic analysis. Compound 1 showed weak antituberculous activity against Mycobacterium tuberculosis H37Ra, and antibacterial activity against Bacillus cereus with MIC values of 25 and 12.5 µg/mL, respectively.
Asunto(s)
Aldehídos/aislamiento & purificación , Antibacterianos/aislamiento & purificación , Benzofuranos/aislamiento & purificación , Hongos/química , Aldehídos/farmacología , Antibacterianos/química , Antibacterianos/farmacología , Bacillus cereus/efectos de los fármacos , Biología Marina , Pruebas de Sensibilidad Microbiana , Estructura Molecular , Mycobacterium tuberculosis/efectos de los fármacos , Análisis EspectralRESUMEN
Nine alliacane sesquiterpenoids, inonoalliacanes A-I, were isolated from culture broth of the basidiomycete Inonotus sp. BCC 22670. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The absolute configuration of inonoalliacane F was determined by application of the modified Mosher's method. Inonoalliacane A, the most abundant sesquiterpene constituent, exhibited moderate antibacterial activity against Bacillus cereus, whereas inonoalliacane B showed antiviral activity against herpes simplex virus type 1.
Asunto(s)
Antibacterianos/aislamiento & purificación , Basidiomycota/química , Sesquiterpenos/aislamiento & purificación , Antibacterianos/química , Antibacterianos/farmacología , Bacillus cereus/química , Pruebas de Sensibilidad Microbiana , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Sesquiterpenos/química , TailandiaRESUMEN
Stereumins Q-U, together with known stereumins A, B, K, L, and N, as well as ent-strobilols E and G were isolated from the culture of Stereum cf. sanguinolentum BCC 22926. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations of stereumins A and Q, as well as ent-strobilol E were established by application of the modified Mosher's method. Stereumin T displayed antibacterial activity against Bacilluscereus with a MIC value of 3.97µM.
Asunto(s)
Antibacterianos/aislamiento & purificación , Bacillus cereus/efectos de los fármacos , Basidiomycota/química , Sesquiterpenos/aislamiento & purificación , Antibacterianos/química , Antibacterianos/farmacología , Pruebas de Sensibilidad Microbiana , Estructura Molecular , Sesquiterpenos Policíclicos , Sesquiterpenos/química , Sesquiterpenos/farmacología , Sesterterpenos , TailandiaRESUMEN
A new cyclohexadepsipeptide, conoideocrellide A (1), its linear derivatives, conoideocrellides B-D (2-4), three new hopane triterpenoids (5-7), two new bioxanthracenes (9 and 10), and a new isocoumarin glycoside (13) were isolated from the scale insect pathogenic fungus Conoideocrella tenuis BCC 18627. Biological activities of the new compounds were evaluated.
Asunto(s)
Antracenos/química , Antracenos/aislamiento & purificación , Antracenos/farmacología , Antineoplásicos/aislamiento & purificación , Depsipéptidos/aislamiento & purificación , Depsipéptidos/farmacología , Glicósidos/aislamiento & purificación , Glicósidos/farmacología , Hemípteros/microbiología , Hypocreales/química , Isocumarinas/aislamiento & purificación , Isocumarinas/farmacología , Triterpenos/aislamiento & purificación , Triterpenos/farmacología , Animales , Antineoplásicos/química , Antineoplásicos/farmacología , Chlorocebus aethiops , Depsipéptidos/química , Ensayos de Selección de Medicamentos Antitumorales , Glicósidos/química , Herpesvirus Humano 1/efectos de los fármacos , Isocumarinas/química , Estructura Molecular , Plasmodium falciparum/efectos de los fármacos , Triterpenos/química , Células VeroRESUMEN
Two new triterpenes, 17(21)-hopene-6alpha,12beta-diol (1) and 17(21)-hopen-12beta-ol (2), the known 17(21)-hopen-6alpha-ol (zeorinin, 3), and two new biarylic dihydronaphthopyrones, aschernaphthopyrones A (4) and B (5), were isolated from the scale insect pathogenic fungus Aschersonia paraphysata BCC 11964. Hopene 1 and aschernaphthopyrone A (4) exhibited antimalarial activity with IC(50) values of 15 and 7.3 microM, respectively.
Asunto(s)
Antimaláricos/aislamiento & purificación , Antimaláricos/farmacología , Hypocreales/química , Naftalenos/aislamiento & purificación , Naftalenos/farmacología , Plasmodium falciparum/efectos de los fármacos , Pironas/aislamiento & purificación , Pironas/farmacología , Triterpenos/aislamiento & purificación , Triterpenos/farmacología , Animales , Antimaláricos/química , Chlorocebus aethiops , Resistencia a Múltiples Medicamentos/efectos de los fármacos , Ensayos de Selección de Medicamentos Antitumorales , Femenino , Humanos , Concentración 50 Inhibidora , Insectos/microbiología , Células KB , Estructura Molecular , Naftalenos/química , Pironas/química , Tailandia , Triterpenos/química , Células VeroRESUMEN
New phenolic mono- and digalactopyranosides (1 and 2), their aglycone KS-501a (3), and a new phenolic 4-O-methylglucopyranoside (4) were isolated from the filamentous fungus Acremonium sp. BCC 14080. Structures of these compounds were elucidated by extensive MS and NMR spectroscopic analyses. Compound 1 displayed anti-HSV-1 activity with an IC(50) value of 7.2 microM. Compound 3 exhibited activity against Plasmodium falciparum K1 with an IC(50) value of 9.9 microM.