RESUMEN
Here we describe a method of forming large arrays (up to 10(9) pieces) of free magnetic Ni-nanodisks 50 nm thick coated on both sides with layers of 5 nm thick Au. The antitumor effect of the magnetic nickel gold-coated nanodisks and DNA aptamer conjugates was evaluated in vivo and in vitro. Under the influence of rotating magnetic field, the studied nanodisks can cause the death of Ehrlich ascites carcinoma cells.
Asunto(s)
Antineoplásicos/administración & dosificación , Aptámeros de Nucleótidos/administración & dosificación , Carcinoma de Ehrlich/tratamiento farmacológico , Nanopartículas del Metal/química , Animales , Antineoplásicos/uso terapéutico , Aptámeros de Nucleótidos/uso terapéutico , Línea Celular Tumoral , Oro/química , Campos Magnéticos , Masculino , Nanopartículas del Metal/efectos adversos , Ratones , Ratones Endogámicos ICR , Níquel/químicaRESUMEN
Chronic pyopolypous pansinusitis in a patient presenting with mucopyocele of the frontal sinus is described. A brief characteristic of cyst-like extension of the paranasal sinuses is presented. Special attention is given to the main diagnostic criteria. The methods of surgical and postoperative treatment of patients with the pathology in question are discussed.