RESUMEN
Dengue fever is classified as one of the most common viral diseases with a transmission mechanism implemented through arthropod vectors. The expansion of of the Aedes aegypti mosquito is leading to a significant increase in the number of cases of dengue fever in more than 100 countries, highlighting the importance of developing and implementing specific prevention and treatment measures. Etiotropic drugs with proven efficacy against the pathogen are not registered, and the use of the vaccine is approved only among seropositive individuals. In this regard, pathogenetic treatment remains the main therapeutic strategy, however, work on the synthesis of antiviral drugs is being actively carried out. Due to the unique functions of non-structural proteins NS3 and NS5 in the viral replication cycle, they have become the main targets for studying the antiviral activity of a number of chemotherapy drugs. Of these proteins, due to the most conserved structure, the NS5 protein is a promising target for inhibition, however, success in obtaining a clinical effect using a number of available antiviral drugs has not been reached. This study describes the positive experience of using the nucleoside analogue riamilovir in the treatment of a patient with dengue fever in the Republic of Guinea.
Asunto(s)
Virus del Dengue , Dengue , Animales , Humanos , Virus del Dengue/fisiología , Replicación Viral , Antivirales/farmacología , Antivirales/uso terapéutico , Guinea , Mosquitos Vectores , Dengue/tratamiento farmacológicoRESUMEN
Current methods for bladder cancer investigation involve cystoscopy, ultrasound scanning, and contrast urography, with additional information provided by cytology. These methods, although having a high detection rate, are expensive, time-consuming, invasive, and uncomfortable. Therefore, there is a need for an inexpensive, non invasive, quick, and simple investigation with a high sensitivity and specificity. In this study we evaluate the use of an in vivo electromagnetic (EM) interaction as a non invasive method for detecting cancer. A clinical trial was designed and completed. The main trial target was the feasibility assessment of the novel method by comparing its results with standard cystoscopy. A physical discussion of the EM interaction with bladder cancer tissue is presented. One hundred and fourteen patients referred for cystoscopy by microscopic or gross haematuria, irritative voiding symptoms, or suspected bladder tumor at ultrasound were first submitted to EM scan by means of the TRIMprob system. Cystoscopy was performed on each patient after the TRIMprob examination. Comparison between EM and cystoscopy results provides a high level of agreement (Cohen's K = 0.77, p < 0.001). The TRIMprob performance in malignant cancer cells detection suggests that this in vivo EM waves method is also worth investigating for routine diagnostic procedures.
Asunto(s)
Campos Electromagnéticos , Neoplasias de la Vejiga Urinaria/diagnóstico por imagen , Neoplasias de la Vejiga Urinaria/diagnóstico , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Computadores , Diagnóstico por Imagen/métodos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Radiografía , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Programas InformáticosRESUMEN
The peculiarities of lipid peroxidation (LPO) and antioxidant defence of Leghorn hens in ontogenesis were studied. The action of stibyl biogeneous preparation in complex with dymethylsulfoxide and distinol synthetic preparation on hen organism antioxidant defence parameters were estimated. The results show that the antioxidant preparations don't render any effect on CAT and GPX activities, meanwhile SOD activity declines under antioxidant influence in the first period of feeding (7-35 days) but increases in the repeated administration admixtures (98-126 days) in comparison with the control group. Administration of antioxidants with fodder is accompanied by increasing the carotinoids, vitamins A and E content and mM levels decrease in hepatic tissue.