RESUMEN

Acyclic analogs of thymidine, adenine, and cytosine where the ribose moiety is replaced with cis-5-hydroxypenthene, were obtained via condensation of cis-5-acetoxy-1-bromo-2-pentene with nucleic acid bases. Triphosphate derivatives of the new nucleosides were also synthesized to evaluate their action as terminators of DNA synthesis catalyzed by DNA polymerases.

Asunto(s)

Nucleósidos/síntesis química , Catálisis , ADN/biosíntesis , ADN Polimerasa Dirigida por ADN/química , Ácidos Nucleicos/química , Nucleósidos/química , Regiones Terminadoras Genéticas