RESUMEN
This research is the first to use ß-sitosterol on myocardial and renal tissues in renal ischemia/reperfusion (IR) damage. Female Wistar rats were randomly divided into three groups: control (sham), renal IR (50 min ischemia - 3 h reperfusion), and renal IR + 150 mg/kg/p.o. ß-sitosterol (the rats were treated with ß-sitosterol orally once 1 h before the IR procedure). ß-Sitosterol pretreatment caused an increase in superoxide dismutase and glutathione activities and a decrease in malondialdehyde levels in the kidney and heart. Moreover, it alleviated histopathological changes and downregulated the levels of tumor necrosis factor-alpha and interleukin-6 and upregulated the levels of endothelial nitric oxide synthase. As conclusion, the potential of ß-sitosterol for renal and cardiac necrosis and apoptosis appears to act by limiting inflammatory response and oxidative stress. Thus, the potential of this compound is noteworthy and may serve as a potential therapeutic in the treatment of acute organ damages due to renal IR.
Asunto(s)
Antiinflamatorios/uso terapéutico , Hipolipemiantes/uso terapéutico , Isquemia/tratamiento farmacológico , Enfermedades Renales/tratamiento farmacológico , Sustancias Protectoras/uso terapéutico , Daño por Reperfusión/tratamiento farmacológico , Sitoesteroles/uso terapéutico , Animales , Antiinflamatorios/farmacología , Apoptosis/efectos de los fármacos , Femenino , Glutatión/metabolismo , Hipolipemiantes/farmacología , Interleucina-6/metabolismo , Isquemia/metabolismo , Isquemia/patología , Riñón/efectos de los fármacos , Riñón/metabolismo , Riñón/patología , Enfermedades Renales/metabolismo , Enfermedades Renales/patología , Malondialdehído/metabolismo , Miocardio/metabolismo , Miocardio/patología , Óxido Nítrico Sintasa de Tipo III/metabolismo , Sustancias Protectoras/farmacología , Ratas Wistar , Daño por Reperfusión/metabolismo , Daño por Reperfusión/patología , Sitoesteroles/farmacología , Superóxido Dismutasa/metabolismo , Factor de Necrosis Tumoral alfa/metabolismoRESUMEN
Superficial basal cell carcinomas (BCC) comprise 9% to 11% of BCC, and are commonly found on the trunk or limbs. We report a case of a superficial BCC on the scalp that was misdiagnosed and treated as seborrhoeic dermatitis. Any erythematous plaque-type lesion of long duration must have superficial BCC considered in the differential diagnosis.