RESUMEN

Biological properties of a novel vasopressin analogue were investigated. It was found that this analogue has no vasopressor and oxytocic activities but it exhibits a selective antidiuretic effect which is weaker than that of adiuretin (DDAVP). Novel analogue inhibits vasopressor, oxytocic and antidiuretic effects caused by arginine--vasopressin. The usefulness of novel compound as a pharmacological tool--vasopressin antagonist is suggested.

Asunto(s)

Arginina Vasopresina/análogos & derivados , Arginina Vasopresina/antagonistas & inhibidores , Diuréticos/antagonistas & inhibidores , Animales , Arginina Vasopresina/administración & dosificación , Arginina Vasopresina/farmacología , Desamino Arginina Vasopresina/farmacología , Femenino , Masculino , Ratas , Factores de Tiempo