RESUMEN
Insufficient fitness of experimental data with convenient linear and linear-quadratic models of "dose-effect" dependence for the number of chromosome aberrations of different types were revealed. Proposed method of approximation of the experimental "dose-effect" dependence with piece-linear splines allows to obtain more accurate results in the most cases and therefore is more preferable than the linear and linear-quadratic models.
Asunto(s)
Cromosomas Humanos/efectos de la radiación , Relación Dosis-Respuesta en la Radiación , Linfocitos/efectos de la radiación , Células Cultivadas , Aberraciones Cromosómicas , Isótopos de Cobalto , Rayos gamma , Humanos , Linfocitos/citología , Modelos BiológicosRESUMEN
The study is of a retrospective character and is based on the author's own cytogenetic findings secured in May-June 1986 in the examination of patients diagnosed as having had a first to third-degree acute radiation sickness while receiving massive detoxicating therapy. We consider it expedient to employ the model of multiple linear regression relying on a complex of most informative cytogenetic indicators rather than on only one such indicator alongside the traditional dose reaction identifiable by the level of dicentric chromosomes in blood lymphocytes. This will allow the degree of severity of the radiation injury to be determined with greater precision and permits assessing the therapeutic efficiency of the measures implemented.
Asunto(s)
Aberraciones Cromosómicas/genética , Centrales Eléctricas , Traumatismos por Radiación/genética , Liberación de Radiactividad Peligrosa , Índice de Severidad de la Enfermedad , Enfermedad Aguda , Humanos , Modelos Lineales , Liberación de Radiactividad Peligrosa/estadística & datos numéricos , Estudios Retrospectivos , Factores de Tiempo , UcraniaRESUMEN
The estimation of the malignancy-associated changes in oral mucosa of patients with benign and malignant processes in mammary and thyroid gland is carried out on the basis of textural and densitometric indices of the interphase nuclei of the epitheliocytes with the help of the methods of mathematical statistics.
Asunto(s)
Neoplasias de la Mama/ultraestructura , Mucosa Bucal/ultraestructura , Neoplasias de la Tiroides/ultraestructura , Adenocarcinoma/ultraestructura , Núcleo Celular/ultraestructura , Mejilla , Técnicas Citológicas/estadística & datos numéricos , Células Epiteliales/ultraestructura , Femenino , Fibroadenoma/ultraestructura , Bocio Nodular/patología , Humanos , Interfase , Lesiones Precancerosas/ultraestructura , Tiroiditis Autoinmune/patologíaRESUMEN
Retrospective estimation of the prognostic importance of parameters, that are different in biological essence, for the persons that have died from malignant melanoma of the skin with use of the adequate mathematical approaches is carried out. A spectrum of important cytogenetic, morphologic and clinical factors which have influence on the prognosis of disease is determined. For group of living patients the prognosed survival time are individually calculated.