RESUMEN

Certain hollow organs are known to form cysts when heterologously transplanted. In order to examine the usefulness of the phenomenon for regenerative medicine, rat urinary bladders and other organs were allo-transplanted under the subcutaneous tissue of the back. These transplanted tissues very often formed cysts covered with epithelia. The epithelia covered an area about twice the original size. In the case of the urinary bladder, the epithelium started moving from the edge of the transplants around day 3 after the operation, and as time proceeded, the tela submucosa and tunica muscularis also moved to encircle the epithelium, and formed the wall of the cyst. The basal laminae were formed under the newly expanded epithelium slightly behind the leading tip. All of the organs tested had the capability of cyst formation and epithelialization, although their rate differed between organs. The results are discussed with reference to the potential use of cyst formation for regenerating damaged organs.

Asunto(s)

Trasplante de Órganos/métodos , Regeneración/fisiología , Vejiga Urinaria/fisiología , Vejiga Urinaria/trasplante , Animales , Quistes/fisiopatología , Fenómenos Fisiológicos del Sistema Digestivo , Procedimientos Quirúrgicos del Sistema Digestivo , Epitelio/fisiología , Ratas , Ratas Wistar , Fenómenos Fisiológicos de la Piel , Tejido Subcutáneo , Tráquea/fisiología , Tráquea/trasplante

RESUMEN

Skins and hollow organs have been shown to form epithelialized cysts when transplanted into subcutaneous tissue of a recipient animal, expanding their surface areas. This system seems to offer a good potential for regenerating organs. We investigated the functional and structural contribution of epithelia and connective tissue compartments in this regeneration system with two experimental systems.