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1.
Am J Pharm Educ ; 41(3): 333, 1977 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-10236659
4.
J Pharm Sci ; 64(10): 1647-51, 1975 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-171374

RESUMEN

Minimally effective oral doses of chlorpromazine, imipramine, and pentobarbital necessary to block a discrete trial (bar-press) conditioned avoidance response were compared in cats chronically implanted with electrodes over the cerebral cortex and in the nucleus centralis medialis of the thalamus. Three conditioned stimulus contingencies consisting of tone and low or high voltage thalamic stimulation were presented. Minimal conditioned response blocking doses of these agents produced only slight qualitative changes in cortically recorded recruitment. Drug treatment affected the conditioned stimulus contingencies differentially, and the rank order in terms of ease of disruption of the conditioned avoidance response was high voltage thalamic conditioned stimulus greater than low voltage thalamic conditioned stimulus greater than auditory conditioned stimulus. The differential effect of these drugs might have been due to the additive inhibition of these agents and the thalamic conditioned stimulus on performance. With the exception of chlorpromazine, the behavioral effects of these drugs and their effects on recruitment were dissociated.


Asunto(s)
Estimulación Acústica , Reacción de Prevención/efectos de los fármacos , Reclutamiento Neurofisiológico/efectos de los fármacos , Transmisión Sináptica/efectos de los fármacos , Tálamo/fisiología , Animales , Gatos , Clorpromazina/farmacología , Estimulación Eléctrica , Electrodos Implantados , Electroencefalografía , Femenino , Imipramina/farmacología , Pentobarbital/farmacología
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