RESUMEN

Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A 26-yr-old man presented with painless palpable lymph node in cervical area. Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum. The cervical lymph node biopsy showed dilated sinuses filled with histiocytes with clear cytoplasm. The cells stained positive with CD68 and S-100. These cytologic and immunohistochemical findings were considered consistent with the diagnosis of SHML.

Asunto(s)

Histiocitosis Sinusal/diagnóstico , Derrame Pleural/diagnóstico por imagen , Adulto , Antígenos CD/metabolismo , Antígenos de Diferenciación Mielomonocítica/metabolismo , Histiocitos/patología , Histiocitosis Sinusal/metabolismo , Histiocitosis Sinusal/patología , Humanos , Ganglios Linfáticos/patología , Masculino , Cuello , Proteínas S100/metabolismo , Tomografía Computarizada por Rayos X