RESUMEN
Forty-three persons chronically exposed to vinyl chloride were examined. In their blood serum activity of AlAT and AspAT aminotransferases, alkaline phosphatase, concentration of total protein and electrophoretic fraction, thymol test value, concentration of ferrum, latent and total ability of ferrum binding, and transferrin ferrum saturation coefficient were determined. In addition, determined were bromsulphtaleinic test and J-131 labelled Bengal red test; furthermore, protein synthesis index was determined, using the Se-75 labelled selenemethionine. The test group, as compared to correct values, exhibited a significant increase in Fe concentration in serum, significantly prolonged Bengal rose decay halftime in blood, and statistically significant decrease in the rate of plasma protein synthesis. The greatest percentage of pathological results was that of the index of protein synthesis rate (50%), T1/2 of CBJ-131 activity decay (39.5%), transferrin ferrum saturation coefficient (30.4%), concentration of Fe (26.1%) and gammaglobuline (24.3%) in serum. A considerable part of the reduced protein synthesis index in the test group of workers pointed to its usability for detecting early disturbances in liver functioning.
Asunto(s)
Contaminantes Ocupacionales del Aire/efectos adversos , Proteínas Sanguíneas/análisis , Pruebas de Función Hepática , Cloruro de Vinilo/efectos adversos , Compuestos de Vinilo/efectos adversos , Adulto , Alanina Transaminasa/sangre , Fosfatasa Alcalina/sangre , Aspartato Aminotransferasas/sangre , Enfermedad Hepática Inducida por Sustancias y Drogas/diagnóstico , Humanos , Hígado/fisiopatología , Persona de Mediana Edad , Enfermedades Profesionales/inducido químicamente , Enfermedades Profesionales/diagnóstico , Factores de TiempoRESUMEN
The subject of the paper has been to check the aminolevulinic dehydratase (ALAD) activity in those with no occupational exposure to inhibitors of this enzyme. Altogether 293 persons have been examined, 132 women and 161 men, aged 20-69. The resultant ALAD activity distribution showed no differences between women and men, though statistically significant differences have been found between the mean values. The distribution did not deviate from normal in both groups. The analysis of ALAD activity distribution in particular age groups, whether female or male, showed statistically significant differences. No clear dependence between ALAD activity and haemoglobin concentration in blood has been found. On the other hand, clear differences in ALAD activity between groups of high and low haemoglobin concentrations have been found. In addition to the mentioned examinations, 32 persons (12 women and 20 men) presently exposed to lead had their lead concentration determined in blood. No correlations have been found between lead concentrations in blood and ALAD activity.
Asunto(s)
Eritrocitos/enzimología , Porfobilinógeno Sintasa/sangre , Adulto , Factores de Edad , Anciano , Femenino , Hemoglobinas/análisis , Humanos , Plomo/sangre , Masculino , Persona de Mediana Edad , Factores SexualesRESUMEN
Djuricz's antabus test has been applied in a group chronically exposed to carbon disulphide. Sixty eight viscose industry workers hospitalized in the Clinic of Occupational Diseases, Institute of Occupational Medicine, Lódz, have been examined along with controls. In all subjects, after oral administration of antabus, the content of diethyldithiocarbamates (DDC) was determined in a 5 hr urine sample. The mean values of excreted DDC have indicated a statistically significant decrease in those chronically CS2 exposed, as compared to the controls. The dependence of DDC excretion on the duration of work in exposure has indicated a clear decrease in the values in those chronically exposed as compared to those exposed for a short time. The obtained results confirm the observations of other authors on DDC excretion decrease in CS2 exposed workers, demonstrating simultaneously some effects of chronic CS2 exposure on antabus metabolism.
Asunto(s)
Contaminantes Ocupacionales del Aire/toxicidad , Contaminantes Atmosféricos/toxicidad , Disulfuro de Carbono/toxicidad , Disulfiram , Ditiocarba/orina , Tiocarbamatos/orina , Adulto , Humanos , Masculino , Persona de Mediana Edad , Factores de TiempoRESUMEN
The paper was aimed at an evaluation of nonspecific humoral resistance in CS2 chronically exposed workers. The studies covered 68 men of medium, 16 years, duration of employment in exposure and 20 controls. In all subjects the concentration of lysozyme and some ferrum economy parameters were determined. In the group of chronically CS2 exposed workers the serum lysozyme index was found to be statistically significantly decreased. In addition, in 14.7% of subjects, increased ferrum concentration and increased index of plasmatic transferin saturation with ferrum were found as well as statistically significant decrease in lysozyme concentration and index. The observed changes in the parameters concerned, contributing to the system of humoral nonspecific resistance may result in an increased infectious diseases incidence among the CS2 exposed workers.
Asunto(s)
Formación de Anticuerpos/efectos de los fármacos , Disulfuro de Carbono/envenenamiento , Hierro/sangre , Muramidasa/sangre , Enfermedades Profesionales/inducido químicamente , Infecciones Bacterianas/inmunología , Humanos , Masculino , Factores de Tiempo , Transferrina/sangreRESUMEN
To blood samples taken from persons who are not exposed to the effect of lead, ions Pb++ were added. Then lowering of the activity of aminolevulinic dehydratase (ALAD) in proportion to an amount of lead added was observed. Parallel introduction of ions Pb++ and EDTA prevented a significant lowering of ALAD activity. The persons who were exposed to chronic effect of lead, with a lowered activity of ALAD, were given EDTA, as a treatment. Significant increase in the form of doubled activity of the enzyme occurred in the period between 8-16 day of treatment.