RESUMEN
Addition of (intramuscular+intravenous) leukinferon (LF) to the schemes for the treatment of acute peritonitis promoted a more rapid positive development of the time course of clinical signs and decreasing of leukocytosis in the presence of a pronounced tendency to normalization of the main immunological indices i. e. the counts of differential T-lymphocytes and T-helper cells. There was also activation of neutrophil phagocytic function. A rapid decrease in objective signs of endotoxicosis was recorded: the intoxication leukocytic index and the level of medium-mass molecules. In parallel with the decrease in the intoxication leukocytic index, there was a decrease in cytosis of the peritoneal exudate. The use of LF in the treatment of elderly patients with acute cholecystitis eliminated the clinical signs and normalized the main laboratory indices without surgical interventions which allowed one to make a planned operation with the minimum risk.
Asunto(s)
Adyuvantes Inmunológicos/uso terapéutico , Colecistitis/terapia , Citocinas/uso terapéutico , Interferón Tipo I/uso terapéutico , Neutrófilos/efectos de los fármacos , Peritonitis/terapia , Fagocitosis/efectos de los fármacos , Linfocitos T/efectos de los fármacos , Enfermedad Aguda , Adyuvantes Inmunológicos/administración & dosificación , Adulto , Colecistitis/inmunología , Citocinas/administración & dosificación , Combinación de Medicamentos , Humanos , Inyecciones Intramusculares , Inyecciones Intravenosas , Interferón Tipo I/administración & dosificación , Recuento de Leucocitos/efectos de los fármacos , Masculino , Neutrófilos/inmunología , Peritonitis/inmunología , Fagocitosis/inmunología , Linfocitos T/inmunologíaRESUMEN
In response to virus induction a culture of donor leukocytes alongside with interferon (IF-alpha) produced a factor of tumor necrosis (TNF). The kinetics of TNF and IF-alpha biosynthesis did not depend on the kind of IF used for priming, was rapid, with maximum production within 7-8 hours. Antibodies to IF-alpha and IF-alpha had no effect on TNF production, while antibody to TNF did not reduce IF-alpha yields. TNF in detectable titres was present in medical preparations of native IF-alpha but was absent in preparations of recombinant IF-alpha and IF-alpha as well as in an injection preparation of IF purified by chemical methods.