RESUMEN
A new chromanone derivative, namely caloinophyllin A (1), along with eight known compounds (2-9), nobiletin (2), pentamethylquercetin (3), 3,5,7,4'-tetramethoxyflavone (4), 5,7,4'-trimethoxyflavone (5), 1,5-dihydroxyxanthone (6), 1,8-dimethoxy-2-hydroxyxanthone (7), 1,6-dihydroxy-7-methoxyxanthone (8) and 4-methoxycaffeic acid (9) were isolated from the roots of Calophyllum inophyllum. The structures of all the isolated compounds (1-9) were fully characterised using spectroscopic data, as well as comparison with the previous literature data. In addition, the quantum chemical calculation has been used to confirm the conformation of 1. Moreover, all isolated compounds were assessed for their in vitro cytotoxicity against five human cancer cell lines.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Calophyllum/química , Cromanos/aislamiento & purificación , Antineoplásicos Fitogénicos/farmacología , Línea Celular Tumoral , Cromanos/farmacología , Humanos , Estructura Molecular , Fitoquímicos/aislamiento & purificación , Fitoquímicos/farmacología , Raíces de Plantas/química , Tailandia , Xantonas/química , Xantonas/aislamiento & purificaciónRESUMEN
Strychnuxin (1), a new non-glucosidic iridoid, together with four known compounds, IX (2), loganetin (3), loganin (4) and sweroside (5), were isolated from the roots of Strychnos nux-blanda. The structures of all isolated compounds (1-5) were elucidated through their physical properties and by the use of spectroscopic methods, as well as comparisons with the previous literature. To the best of our knowledge, this is the first isolation of compounds 1-5 from this plant. All isolated compounds were evaluated for their in vitro cytotoxicity against five human cancer cell lines.
Asunto(s)
Medicamentos Herbarios Chinos/química , Iridoides/química , Strychnos/química , Línea Celular Tumoral , Proliferación Celular/efectos de los fármacos , Medicamentos Herbarios Chinos/aislamiento & purificación , Medicamentos Herbarios Chinos/farmacología , Humanos , Iridoides/aislamiento & purificación , Iridoides/farmacología , Espectroscopía de Resonancia Magnética , Estructura Molecular , Raíces de Plantas/químicaRESUMEN
Two new depsidones, schomburgdepsidones A and B (1 and 2), and one new xanthone, schomburgxanthone A (3), together with eight known compounds (4-11) were isolated from the roots of Garcinia schomburgkiana. Their chemical structures were established on the basis of spectroscopic analysis. The in vitro cytotoxicity of all 11 compounds was evaluated against the KB, HeLa S-3, HT-29, MCF-7 and Hep G2 human cancer cell lines. Compound 7 performed a good cytotoxicity against the KB, Hela S-3 and MCF-7 cell lines with IC50 values in the range of 3.17-6.07µM. Compound 3 exhibited a good cytotoxicity against the KB cell line only, with an IC50 value of 8.14µM.
Asunto(s)
Antineoplásicos Fitogénicos/química , Depsidos/química , Garcinia/química , Lactonas/química , Xantonas/química , Antineoplásicos Fitogénicos/aislamiento & purificación , Línea Celular Tumoral , Depsidos/aislamiento & purificación , Humanos , Concentración 50 Inhibidora , Lactonas/aislamiento & purificación , Estructura Molecular , Extractos Vegetales/química , Raíces de Plantas/química , Xantonas/aislamiento & purificaciónRESUMEN
The chemical investigation of the crude ethyl acetate extract from Pterocarpus indicus stems led to isolation of a new coumarin, indicusane (1), together with eleven known compounds (2-12). To the best of our knowledge, all isolated coumarins (1-12) are reported for the first time from this plant. Their structures were identified on the basic of spectroscopic data (NMR, MS and ECD) as well as a chemical reaction (Mosher's method). In addition, all isolates were also evaluated for their cholinesterase (ChEs) inhibitory activities, in which only compound 4 exhibited the moderate activity toward AChE and BChE.
Asunto(s)
Cumarinas/farmacología , Extractos Vegetales/química , Tallos de la Planta/química , Pterocarpus/química , Inhibidores de la Colinesterasa/aislamiento & purificación , Inhibidores de la Colinesterasa/farmacología , Cumarinas/aislamiento & purificación , Estructura Molecular , TailandiaRESUMEN
Chemical investigation of the CH2Cl2 and MeOH crude extracts of the roots of Melodorum fruticosum Lour. led to the isolation of 15 known compounds, of which 5, 10, and 12-15 are reported for the first time from this plant. In addition, melodorinol (7) was derivatized to afford six new (7a-7d and 7f-7g) analogues and one known compound (7e). Their structures were identified on the basic of spectroscopic data Most of them were evaluated for their cytotoxicity against KB, HeLa, MCF-7 and HepG-2 cell lines. Compounds 4 and 7b were the most potent to all cell lines.
Asunto(s)
Alquenos/química , Annonaceae/química , Raíces de Plantas/química , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Línea Celular Tumoral , Humanos , Estructura MolecularRESUMEN
Three new furoquinoline alkaloids, leptanoines A-C (1-3) along with three known compounds (4-6) were isolated from the leaves of Evodia lepta. Their structures were identified by interpretation of their spectroscopic data as well as comparison with those reported in the literature. In addition, all isolated compounds were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. Compound 4 showed the highest inhibitory activity towards BChE with an IC50 value of 47.9 µM. On the other hand, Compound 5 showed the highest inhibitory activity towards AChE with an IC50 value of 69.1 µM.
Asunto(s)
Inhibidores de la Colinesterasa/aislamiento & purificación , Evodia/química , Extractos Vegetales/química , Hojas de la Planta/química , Acetilcolinesterasa/metabolismo , Butirilcolinesterasa/metabolismo , Inhibidores de la Colinesterasa/química , Inhibidores de la Colinesterasa/farmacología , Concentración 50 Inhibidora , Estructura MolecularRESUMEN
Three new apotirucallanes (1-3) were isolated from the leaves of Walsura trichostemon. Their structures were identified by interpretation of their spectroscopic data as well as comparison with those reported in the literature. In addition, all isolated compounds were evaluated for their cytotoxicity against KB and HeLa cells.
Asunto(s)
Antineoplásicos/química , Meliaceae/química , Triterpenos/química , Antineoplásicos/toxicidad , Línea Celular Tumoral , Células HeLa , Humanos , Hojas de la Planta/química , Triterpenos/toxicidadRESUMEN
Trichostemonoate (1), a new tirucallane, together with four known compounds, 11α,20-dihydroxydammar-24-ene-3-one (2), sapelin E acetate (3), grandifolinolenenone (4) and α-mangostin (5), were isolated from the stem bark of Walsura trichostemon. The structural assignment of the new compound was based on spectroscopic methods. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines.
Asunto(s)
Antineoplásicos Fitogénicos/química , Meliaceae/química , Corteza de la Planta/química , Extractos Vegetales/química , Triterpenos/química , Antineoplásicos Fitogénicos/farmacología , Línea Celular Tumoral , Humanos , Estructura Molecular , Extractos Vegetales/farmacología , Triterpenos/farmacologíaRESUMEN
From the chemical investigation of the methanolic extract of the roots of the Thai dipterocarp, Dipterocarpus tuberculatus, two new oligostilbene glycosides, dipterostilbenes A (1) and B (2), were isolated together with four known stilbenes. Their structures and relative configurations were determined on the basis of spectroscopic data. From an evaluation of cytotoxic activity against KB and HeLa cell lines, α-viniferin (5) and (-)-hopeaphenol (6) showed potent activity, but less than that of doxorubicin.
Asunto(s)
Glicósidos/química , Magnoliopsida/química , Extractos Vegetales/química , Estilbenos/química , Línea Celular , Proliferación Celular/efectos de los fármacos , Glicósidos/farmacología , Humanos , Estructura Molecular , Extractos Vegetales/farmacología , Estilbenos/farmacologíaRESUMEN
A new 3beta-O-vanilloyl-taraxerol, microcisin (1) and eight known compounds, 3beta-taraxerol acetate (2), 3beta-taraxerol (3), cholest-4-en-3-one (4), cholest-4-en-6beta-ol-3-one (5), beta-sitosterol (6), 7-hydroxycadalene (7), mellein (8) and vanillin (9), were isolated from the roots of Microcos tomentosa. The structures were determined by extensive analysis of their spectroscopic data. All isolated compounds were evaluated for their cytotoxicity against KB and HeLa cells.
Asunto(s)
Ácido Oleanólico/análogos & derivados , Tiliaceae/química , Ensayos de Selección de Medicamentos Antitumorales , Células HeLa , Humanos , Células KB , Ácido Oleanólico/química , Ácido Oleanólico/aislamiento & purificación , Raíces de Plantas/química , Plantas Medicinales/químicaRESUMEN
A new resveratrol dimer, roxburghiol A (1) together with eleven known compounds were isolated from the roots of Shorea roxburghii. Their structures were identified on the basis of spectroscopic evidence and physicochemical properties. All isolated compounds were evaluated for their cytotoxicity (KB and HeLa cells). Compounds 8 and 9 showed potent cytotoxicity against both KB and HeLa cell lines with IC(50) values of 6.5, 8.5 and 8.7, 10.1 µg/mL, respectively.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Dipterocarpaceae/química , Neoplasias/tratamiento farmacológico , Fitoterapia , Extractos Vegetales/química , Estilbenos/aislamiento & purificación , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Antineoplásicos Fitogénicos/uso terapéutico , Células HeLa , Humanos , Concentración 50 Inhibidora , Células KB , Estructura Molecular , Extractos Vegetales/farmacología , Extractos Vegetales/uso terapéutico , Raíces de Plantas , Estilbenos/química , Estilbenos/farmacología , Estilbenos/uso terapéuticoRESUMEN
A new dimeric aporphine, artabotrysine along with five known compounds was isolated from the roots of Artabotrys spinosus. Their structures were fully established on the basis of spectral evidence. All isolated compounds were evaluated for their cytotoxicity on HeLa and KB cells.
Asunto(s)
Annonaceae/química , Aporfinas/aislamiento & purificación , Extractos Vegetales/química , Aporfinas/química , Aporfinas/farmacología , Células HeLa , Humanos , Células KB , Estructura Molecular , Extractos Vegetales/farmacología , Raíces de PlantasRESUMEN
A new 1-azaanthraquinone, named laoticuzanone A (1), and a synthetically known 3-methyl-1H-1-azaanthracene-2,9,10-trione (2), together with four known compounds, Griffithazanone A (3), methyl sinapate (4), methyl p-coumarate (5), and p-hydroxyphenylethyl p-coumarate (6) were isolated from the stems of Goniothalamus laoticus. Their structures were established on the basis of spectroscopic data as well as comparisons with the previous literature data. Compound 1 showed the highest cytotoxicity against KB and HeLa cells with IC(50) values of 0.68 and 0.50 µg/ml, respectively.
Asunto(s)
Antraquinonas/uso terapéutico , Antineoplásicos Fitogénicos/uso terapéutico , Carcinoma de Células Escamosas/tratamiento farmacológico , Goniothalamus/química , Neoplasias de la Boca/tratamiento farmacológico , Extractos Vegetales/uso terapéutico , Neoplasias del Cuello Uterino/tratamiento farmacológico , Antraquinonas/química , Antraquinonas/aislamiento & purificación , Antraquinonas/farmacología , Antineoplásicos Fitogénicos/aislamiento & purificación , Antineoplásicos Fitogénicos/farmacología , Femenino , Células HeLa , Humanos , Concentración 50 Inhibidora , Células KB , Estructura Molecular , Fitoterapia , Extractos Vegetales/química , Extractos Vegetales/farmacología , Tallos de la PlantaRESUMEN
A pair of new isomeric indole alkaloids, naucleaorals A (1) and B (2) were isolated from the roots of Nauclea orientalis. The structures of compounds 1 and 2 were fully characterized using spectroscopic data, and were tested for their cytotoxicity (HeLa and KB cells) and antimalarial activity. Compound 1 showed significant cytotoxicity to HeLa cells with an IC(50) value of 4.0 µg/mL, while compound 2 exhibited very modest cytotoxicity to both cell lines with IC(50) values of 7.8 and 9.5 µg/mL, respectively. Both compounds proved to be inactive in antimalarial assays (IC(50)>10.00 µg/mL).