RESUMEN

We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.

Asunto(s)

Calcio/antagonistas & inhibidores , Calmodulina/antagonistas & inhibidores , Permeabilidad Capilar/efectos de los fármacos , Citotoxinas/antagonistas & inhibidores , Modelos Animales , Trifluoperazina/farmacología , Vibrio vulnificus/patogenicidad , Albúminas/metabolismo , Animales , Calcio/metabolismo , Calmodulina/metabolismo , Línea Celular , Citotoxinas/farmacología , Células Endoteliales/efectos de los fármacos , Células Endoteliales/metabolismo , Ratones , Transporte de Proteínas/efectos de los fármacos , Vibrio vulnificus/química , Vibrio vulnificus/fisiología