RESUMEN
AIM OF INVESTIGATION: To study quality of life (QL) peculiarities in children with chronic gastroduodenitis, Helicobacter pylori positive, in different stages of the disease. METHODS: Quality of life in 60 children (average age--13.06 +/- 1.2 years) with chronic gastroduodenitis was investigated with using adopted SF-36 questionnaire in period of exacerbation of the disease, in 6 weeks after treatment and in period of remission (in 6 months after treatment). 22 healthy children (average age--12.74 +/- 1.14 years) had been taken as a comparison group. RESULTS: Quality of life in children with chronic gastroduodenitis in exacerbation period was significantly worse (p < 0.05) than in healthy children. The more affected scores were the Role physical (RP), Bodily pain with the scores of healthy children. Presence astenic signs in period of remission (in 6 months after treatment) led to worsening of quality of life; the scores were the same and partly worse then before treatment. Applying of neurometabolic therapy improved psycho-emotional status and quality of life. CONCLUSIONS: Quality of life in children with chronic gastroduodenitis was changed with the period of diseases. Initially low scores had tendency to improvement after treatment. In remission period quality of life was mainly depended on peculiarities of psycho-emotional status. Astenic signs led to worsening of quality of life in children with remission of chronic gastroduodenitis. Neurometabolic treatment in this period improved both psycho-emotional status and quality of life.
Asunto(s)
Gastroenteritis/psicología , Infecciones por Helicobacter/psicología , Helicobacter pylori , Calidad de Vida , Adolescente , Niño , Enfermedad Crónica , Estudios de Cohortes , Femenino , Gastroenteritis/fisiopatología , Infecciones por Helicobacter/fisiopatología , Humanos , Masculino , Dimensión del Dolor , Encuestas y CuestionariosRESUMEN
The impact of proteolytic enzymes on the humoral immune response, survival rate and mean survival time of mice, infected with S. aureus culture and receiving antibiotics was studied. Infection with staphylococcal suppressed the formation of antibodies to sheep red blood cells. Ampicillin made this immunosuppression even more pronounced, while gentamicin produced practically no effect on the degree of immunosuppression in the infected animals. Proteolytic enzymes terrilytin and terridecase exhibited immunocorrecting properties when used in combination with antibiotics. Terridecase, the immobilized form of the enzyme proved to have the highest activity. In experimental generalized staphylococcal infection all preparations under study produced a protective effect. The maximum effect was noted after the use of ampicillin in combination with terridecase.
Asunto(s)
Ampicilina/uso terapéutico , Anticuerpos Antibacterianos/biosíntesis , Enzimas Inmovilizadas/uso terapéutico , Gentamicinas/uso terapéutico , Infecciones Estafilocócicas/tratamiento farmacológico , Infecciones Estafilocócicas/inmunología , Animales , Hidrólisis , Ovinos , Staphylococcus aureus/inmunologíaRESUMEN
As revealed in this study, massive burn trauma manifestly suppresses the genesis of antibodies to T-dependent antigen (sheep red blood cells). The administration of ampicillin to the burned animals enhances immunosuppression, while gentamicin produces no essential impact on immune processes under these conditions. Proteolytic enzymes, terrilytin and terridecase, have corrective influence on disturbances in immune response in animals with burns. Enzyme in the immobilized form (terridecase) has a more pronounced immunotropic activity in this type of pathology.
Asunto(s)
Amilasas/uso terapéutico , Antibacterianos/uso terapéutico , Quemaduras/inmunología , Péptido Hidrolasas/uso terapéutico , Infección de Heridas/tratamiento farmacológico , Ampicilina/uso terapéutico , Animales , Formación de Anticuerpos , Quemaduras/microbiología , Combinación de Medicamentos , Enzimas Inmovilizadas , Gentamicinas/uso terapéutico , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos CBA , Staphylococcus aureus , Infección de Heridas/inmunología , Infección de Heridas/microbiologíaRESUMEN
The influence of immobilized proteases such as catalytin (a complex preparation containing the protease terrilytin and the antiseptic catapol) and streptodecase (an activator of fibrinolysis proteases) on the humoral immune response induced by the thymus-dependent antigen (SRBC) under conditions of burns and Staphylococcus infected burns was studied. The immobilized proteases catalytin and streptodecase had an immunostimulating effect under conditions of extended burns. Catalytin had an immunocorrigating effect under conditions of the infected burns. It was suggested that the complex enzyme-containing preparation catalytin and the immobilized activator of fibrinolysis proteases streptodecase were promising immunopharmacological agents in combined treatment of pathological processes accompanied by the development of immune deficiency as a secondary condition.