RESUMEN
BACKGROUND: Saviryata-avadhi (shelf life) of different Ayurvedic dosage forms is described in Sarngadharasamhita. Though the concepts have a strong background, we seek to re-evaluate the age old concepts by following current norms. An attempt has been made in the present study to evaluate shelf-life of Kamsaharitaki avaleha and its granules. MATERIALS AND METHODS: Raw materials were procured from Pharmacy, Gujarat Ayurved University, Jamnagar and utilized after proper authentication in pharmacognosy lab. The avaleha and its granules were prepared in the departmental laboratory following classical guidelines and subjected to accelerated stability studies. RESULTS: Both the products were found to be free from microbial contamination. Heavy metals were within the prescribed limit. Changes in physico-chemical profiles at different intervals are insignificant. On extrapolation of the observations, the shelf life of avaleha was found to be18 months and 27 months to the granules. CONCLUSION: Stability of granules was found to be comparatively higher than the avaleha. This observation may be exclusive to Kamsaharitaki avaleha. Studies on other avalehas and their granules need to be carried out to confirm this preliminary observation.
RESUMEN
INTRODUCTION: Kamsaharitaki Avaleha is a well-known ayurvedic preparation. Considering certain inconveniences of Avaleha, an attempt has been made to convert it into granules that are convenient in handling, dispensing, and storage. AIM: To convert Kamsaharitaki Avaleha into granules form and develop standard manufacturing procedure. MATERIALS AND METHODS: Seven pilot batches were prepared to fix the ratio of formulation composition. The procedure was repeated for 14 times to ensure the process validation. RESULTS: Converting into granules in presence of jaggery and Haritaki pulp is found to be difficult. Replacing these two with Khanda Sharkara and Haritaki powder yielded desired characteristics of granules. CONCLUSION: This modified proportion of ingredients can be considered as standard in preparing Kamsaharitaki Avaleha granules. As no manufacturing and physicochemical properties are available for Kamsaharitaki granules; the current findings can be considered as standard for future studies.