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Herpes simplex virus (HSV) is a frequent cause of oral mucosal ulceration in HIV-seropositive individuals. The case reported here illustrates the clinical presentation, diagnosis, and management of oral ulceration due to HSV.

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Stevens-Johnson syndrome (SJS) is a severe and sometimes lethal form of erythema multiforme most often associated with a drug hypersensitivity reaction. HIV-infected patients suffer a higher incidence of SJS than the general population. This article details a case of nevirapine-induced SJS in an HIV-seropositive man and reviews the clinical features of erythema multiforme, SJS, and their association with drugs commonly used in the treatment of HIV infection.

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Malignant mesothelioma is an aggressive neoplasm originating from the serosal surfaces of the pleural or peritoneal cavity. The following article describes two cases of metastatic mesothelioma to the oral cavity; one involves the tongue, the other involves the mandible. The diagnostic criteria for differentiating metastatic mesothelioma from adenocarcinoma are also discussed.

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Cytomegalovirus is responsible for a significant percentage of asymptomatic viral infections worldwide. Although virtually any cell or organ may be infected, involvement of the oral cavity is uncommon. Only nine well-documented examples of intraoral cytomegalovirus infections were found in a review of the English-language literature. We report six additional examples, five of which possessed unique clinical and histopathologic characteristics. The light and electron-microscopic features of cytomegalovirus are discussed, as well as diagnostic adjuncts such as immunohistochemistry and deoxyribonucleic acid in situ hybridization.

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Epithelioid angiosarcoma is a rare vascular tumor composed of a proliferation of cytologically malignant epithelioid endothelial cells. These tumors are fully malignant and can pursue a rapidly progressive course. A case of primary epithelioid angiosarcoma of the maxilla is presented. Also discussed is a review of the literature with emphasis on the concept of epithelioid endothelial cell tumors.

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Benign fibrous histiocytomas of bone are unusual neoplasms that often are confused with metaphyseal fibrous defects. Although the two lesions have overlapping microscopic characteristics, they differ in their clinicopathologic presentations. This report describes the clinicopathologic features of the first reported case of benign fibrous histiocytoma involving the maxilla and the fourth description of this tumor in the jawbones. In addition, the concept of fibrohistiocytic lesions of bone is discussed with consideration of their pathologic classification and their clinical, radiographic, and microscopic differential diagnosis.

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A total of 3970 cases of Kaposi's sarcoma (KS) associated with the acquired immunodeficiency syndrome had been reported to the Centers for Disease Control by the end of 1986. The prevalence of oral KS in patients with KS of the skin varies, reaching a maximum of 44% in one published study. We present a retrospective clinicopathologic analysis of 23 previously unreported cases of oral KS in male homosexual and bisexual patients from the New York metropolitan area. Our data reveal that 21 of the patients had KS confined to the oral cavity and that, in 16 cases, the oral KS was the first presenting sign of the acquired immunodeficiency syndrome. Sixteen of the 23 patients had solitary oral lesions. Nineteen of the tumors showed prominent endothelium-lined capillaries resembling lymphatics, 16 exhibited a prominent spindle cell component, and 17 demonstrated areas of fibrosis. Of the 13 patients for whom there was adequate follow-up information, five were dead within 6 to 15 months. All five deaths were due to Pneumocystis pneumonia.

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Four cases of an unusual skin eruption related to mandibular block injection are presented. The authors suggest an immunologic basis for the reaction, probably to the methylparaben preseravtive, and discuss a possible pathogenic mechanism. The medical-dental literature concerning untoward reactions to lidocaine is reviewed; particular attention is given alleged allergic reactions.

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A case of trichilemmoma of the upper lip has been presented and the entity is discussed. This particular case, similar to so many others reviewed in the literature, was mistaken for a basal cell carcinoma or verruca.

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The keratoacanthoma is a tumorlike proliferation which is rarely seen in the oral cavity. Both clinically and microscopically, it may bear close resemblance to squamous-cell carcinoma. The following article discusses the keratoacanthoma and, in addition, presents a case report of solitary intraoral keratoacanthoma.

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This article reviews the literature of the papillary cystadenoma of minor salivary gland origin and discusses and attempts to clarify the true nature of these lesions. The criteria for diagnosis are presented, and classification of this lesion based on the Histological Typing of Salivary Gland Tumours (World Health Organization) is suggested. In addition, an interesting variant, which we have called the papillary cystadenoma, mucous-cell type, is presented.

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Desmoplastic fibroma (fibromatosis) is rarely seen as a primary tumor of bone. Its occurrence as a central lesion in the jaws is even more uncommon. The case of a 26-year-old woman with a central desmoplastic fibroma of the body of the mandible is described. The lesion manifested as a painless swelling and radiographically appeared as a well-delineated radiolucency. On exploration, the tumor was found to have infiltrated through the lingual cortex. Microscopic examination revealed invasion of muscle. The clinicopathologic features of this case and of the twenty-five similar lesions previously described in the literature are analyzed and discussed.

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