RESUMEN
BACKGROUND AND OBJECTIVES: School students with specific learning disabilities (SpLDs) endure academic difficulties, anxiety, and social maladaptation. The primary objective of the present study was to evaluate the emotional intelligence (EI) abilities of these afflicted students. Its secondary objective was to analyze the impact of socio-demographic variables on their EI abilities. SETTINGS AND DESIGN: Cross-sectional single-arm questionnaire-based study was conducted in the Learning Disability clinic in a public medical college in Mumbai. SUBJECTS AND METHODS: SpLD students studying in class standards VII-IX were recruited by non-probability sampling. Their EI (overall, subscales, and settings) scores were measured using the Four EsScale of Emotional Intelligence-Adolescents (FESEI-A) questionnaire; and compared with Indian norm scores by utilizing the Mann - Whitney U test. To evaluate the unadjusted impact that each of the "variables" had on the FESEI-A scores, linear regression or the Mann-Whitney U test, or the Kruskal-Wallis test, was utilized as applicable. RESULTS: SpLD students had similar "overall" EI abilities as their regular peers. Their EI scores in school setting were significantly lower (P = 0.001), but significantly higher in social setting (P = 0.005). At univariate level, presence of co-occurring attention-deficit/hyperactivity disorder was significantly associated with a lower "school setting" score (P = 0.040). Higher socioeconomic status was significantly associated with a higher "overall" score and "family setting" score (P = 0.023 and P= 0.041, respectively). CONCLUSIONS: There is an urgent need to evaluate the EI abilities of SpLD students to identify deficits so that optimum rehabilitation can be facilitated.
Asunto(s)
Inteligencia Emocional , Discapacidades para el Aprendizaje , Adolescente , Estudios Transversales , Humanos , India , Discapacidades para el Aprendizaje/epidemiología , Estudiantes/psicología , Encuestas y CuestionariosRESUMEN
Results of a surface complexation model (SCM) for americium sorption on volcanic rocks (devitrified and zeolitic tuff) are presented. The model was developed using PHREEQC and based on laboratory data for americium sorption on quartz. Available data for sorption of americium on quartz as a function of pH in dilute groundwater can be modeled with two surface reactions involving an americium sulfate and an americium carbonate complex. It was assumed in applying the model to volcanic rocks from Yucca Mountain, that the surface properties of volcanic rocks can be represented by a quartz surface. Using groundwaters compositionally representative of Yucca Mountain, americium sorption distribution coefficient (Kd, L/Kg) values were calculated as function of pH. These Kd values are close to the experimentally determined Kd values for americium sorption on volcanic rocks, decreasing with increasing pH in the pH range from 7 to 9. The surface complexation constants, derived in this study, allow prediction of sorption of americium in a natural complex system, taking into account the inherent uncertainty associated with geochemical conditions that occur along transport pathways.
Asunto(s)
Americio/química , Monitoreo de Radiación , Contaminantes Radiactivos del Suelo/química , Erupciones Volcánicas/análisis , Adsorción , Concentración de Iones de Hidrógeno , Modelos Teóricos , Nevada , Propiedades de SuperficieRESUMEN
PURPOSE: To assess the short-term safety and efficacy of an intravitreal injection of bevacizumab in a patient with neovascular glaucoma. CASE REPORT: Intravitreal bevacizumab injection was given in a patient with neovascular glaucoma and the changes in the visual acuity, intraocular pressure (lOP), iris neovascularisation were noted before injection and after one day, one week, three weeks and six weeks. Regression of the iris new vessels and normalization of the intraocular pressure was noted. CONCLUSION: Intravitreal bevacizumab was effective and safe in the short-term in a patient with neovascular glaucoma. It may be a useful adjunctive treatment.
Asunto(s)
Inhibidores de la Angiogénesis/administración & dosificación , Anticuerpos Monoclonales/administración & dosificación , Glaucoma Neovascular/tratamiento farmacológico , Anciano , Anticuerpos Monoclonales Humanizados , Bevacizumab , Diabetes Mellitus Tipo 2/complicaciones , Glaucoma Neovascular/etiología , Humanos , Hipertensión/complicaciones , Masculino , Inducción de RemisiónRESUMEN
Bacterial contamination is a serious problem that causes severe loss of in vitro grown cultures of a number of plants. This problem becomes even more acute if the bacterial contamination is of endophytic origin. In such cases, identification and characterization of the contaminants is essential for achieving specific control of the contaminants through selective use of antibiotic agents, especially if the routinely used contamination control methods practiced elsewhere in tissue culture studies are ineffective. Such is the case with the bacterial contamination observed in the present study. The five endophytic bacteria associated with Piper nigrum and Piper colubrinum, four endophytic bacteria associated with Taxus baccata subsp. wallichiana, two endophytic bacteria associated with Withania somnifera, and two bacteria common to all these plant species were isolated and characterized based on morphological and biochemical tests. Their taxonomic positions based on similarity indices were determined. A control strategy against these bacteria has been developed based on bacteriostatic or bactericidal actions of 12 antibiotics at three different concentrations by solid and liquid antibiogramme assays.
Asunto(s)
Piper/microbiología , Enfermedades de las Plantas/microbiología , Taxus/microbiología , Withania/microbiología , Antibacterianos/farmacología , Bacterias Aerobias/clasificación , Bacterias Aerobias/efectos de los fármacos , Bacterias Anaerobias/clasificación , Bacterias Anaerobias/efectos de los fármacos , Medios de Cultivo , Técnicas In Vitro , Piper/crecimiento & desarrollo , Esterilización/métodos , Taxus/crecimiento & desarrollo , Withania/crecimiento & desarrolloRESUMEN
During serotyping of fecal specimens positive for rotavirus from hospitalized diarrhea patients in Pune, India, about 10% showed multireactivity in enzyme immunoassay with monoclonal antibodies specific for serotypes G1-4, 6, 8, and 10. In order to characterize some of these, three fecal specimens from children and one from adult were culture adapted. All the isolates showed long RNA pattern, but three out of four isolates belonged to subgroup I and II and one, to subgroup I. The isolates were confirmed as G6 by neutralization assay and polymerase chain reaction. Nucleotide sequences of cDNA derived from the gene encoding the outer capsid protein, VP7 of two strains indicated >94% identity with G6, the serotype, generally associated with cattle. The isolates were more close to G6 RF strain, which is a bovine rotavirus, reported from France. This is a first report of isolation of bovine serotype, G6 from children as well as adults from India.
Asunto(s)
Diarrea/virología , Infecciones por Rotavirus/virología , Rotavirus/clasificación , Adulto , Proteínas de la Cápside/genética , Niño Hospitalizado , Heces/microbiología , Humanos , India/epidemiología , Lactante , ARN Viral/análisis , Rotavirus/genética , Rotavirus/aislamiento & purificación , Infecciones por Rotavirus/epidemiología , Alineación de Secuencia , Análisis de SecuenciaRESUMEN
Generally, group A rotaviruses are the most common cause of paediatric diarrhoea. However, group B rotavirus, adult diarrhoea rotavirus (ADRV), was found to be involved in epidemics of severe gastroenteritis in several areas of China during 1982-1983 and had resulted in more than one million cases among adults as well as older children. Human group B rotavirus has been rarely reported outside China, but has been detected first from five adults with diarrhoea in Kolkata, India during 1997-1998 (strain CAL-1). During epidemiological studies at the National Institute of Virology (NIV) on hospitalized diarrhoea patients at Pune, India, faecal specimens from patients of >5 years age, which were negative for group A rotavirus by ELISA were tested by polyacrylamide gel electrophoresis (PAGE). We detected rotavirus RNA migration patterns similar to that of group B rotavirus in three faecal specimens from adults, two from the specimens collected in 1993 and one in 1998 from sporadic diarrhoea cases. RT-PCR was carried out using primers derived from gene 8 which codes for the NS2 protein, followed by nested PCR, which confirmed the presence of group B rotavirus in all three specimens. The sequences of the PCR products of NIV specimens were compared with that of CAL-1, ADRV and IDIR (infectious diarrhoea of infant rat) belonging to group B rotaviruses. The sequence analysis of the PCR products showed the highest identity with CAL-1, which was reported from Kolkata, India during 1997--1998. The finding suggests that human group B rotaviruses have been circulating in Pune. India, since 1993. This emerging virus may lead to more severe disease among adults in India. There is a need for surveillance of group B rotavirus infections, especially in adult diarrhoea cases and seroepidemiological studies on group B rotavirus are required among humans and animals of Western Maharashtra, India.
Asunto(s)
Brotes de Enfermedades , Infecciones por Rotavirus/epidemiología , Infecciones por Rotavirus/virología , Rotavirus/clasificación , Adulto , Secuencia de Aminoácidos , Antígenos Virales/análisis , Diarrea/epidemiología , Diarrea/etiología , Diarrea/prevención & control , Diarrea/virología , Ensayo de Inmunoadsorción Enzimática , Femenino , Humanos , India/epidemiología , Masculino , Datos de Secuencia Molecular , Filogenia , ARN Viral/análisis , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Rotavirus/aislamiento & purificación , Infecciones por Rotavirus/etiología , Infecciones por Rotavirus/prevención & control , Alineación de SecuenciaRESUMEN
BACKGROUND & OBJECTIVES: Rotavirus is the major cause of gastroenteritis in infants and young children all over the world. The objective of the study was to develop a rapid ELISA for the diagnosis of rotavirus infection in children hospitalised with diarrhoea. METHODS: Immune serum was raised in rabbits by inoculating semipurified rotavirus, SA-11 strain. Immunoglobulins were conjugated to horse radish peroxidase and a rapid ELISA for rotavirus diagnosis was developed. The rapid ELISA was compared with routine ELISA, developed earlier at NIV. RESULTS: Of the 155 faecal samples from patients with diarrhoea, 96 were positive by rapid ELISA and 95 in routine NIV ELISA. OD values were higher in rapid ELISA. The rapid ELISA takes only 4 h to complete. INTERPRETATION & CONCLUSION: Rotavirus diagnosis by rapid ELISA is simple and easy to perform. This may lead to a significant reduction in the unnecessary usage of antibiotics, which cannot control infection due to rotavirus. This technology is being commercialized.
Asunto(s)
Diarrea/diagnóstico , Ensayo de Inmunoadsorción Enzimática/métodos , Infecciones por Rotavirus/diagnóstico , Rotavirus/aislamiento & purificación , Niño , HumanosRESUMEN
An epidemic of diarrhoea in Jawhar, a tribal area of Thane district, Maharashtra, India was investigated. Within a period of approximately 2 months 490 cases of acute diarrhoea were reported among children under 5 years of age, with a case fatality rate of 0.40%. Twenty-seven out of 39 (69.23%) rectal swabs/faecal specimens obtained from hospitalized paediatric patients up to 2 years of age from Jawhar were positive by ELISA for rotavirus. Of these, seven were in the age group of < or = 6 months. Seven ELISA-positive faecal specimens were positive for serotype G3 by RT PCR. Out of 15 serum samples collected from these patients, 12 showed the presence of rotavirus-specific IgM. Rotavirus appears to be the aetiological agent of this widespread outbreak in Jawhar, Thane district, Maharashtra state, India.
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Diarrea/epidemiología , Brotes de Enfermedades , Infecciones por Rotavirus/epidemiología , Adolescente , Adulto , Niño , Preescolar , Humanos , India/epidemiología , Lactante , Recién Nacido , Factores de TiempoRESUMEN
An isocratic reversed-phase liquid chromatography method with UV detection has been developed for the purity evaluation of imatinib mesylate in bulk drug. The method is selective and is capable of detecting all process intermediates and other related compounds, which may be present at trace levels in the drug substance. The method was validated on a Symmetry Shield RP18 analytical column (150 x 4.6 mm, 5 microm), mobile phase consisting of 30 mM sodium octane sulphonic acid in 10 mM aqueous KH2PO4 (pH 2.5 with H3PO4): MeOH in the ratio of 42:58 v/v. The flow rate was set at 1.0 ml/min and the column was maintained at room temperature. The injection volume was set to 10 microl and the detector was set at a wavelength of 237 nm. The method was validated in terms of system precision, method precision, linearity, accuracy, limit of detection and limit of quantification.
Asunto(s)
Piperazinas/análisis , Pirimidinas/análisis , Benzamidas , Cromatografía Liquida/métodos , Contaminación de Medicamentos/prevención & control , Mesilato de Imatinib , Piperazinas/química , Pirimidinas/química , Reproducibilidad de los ResultadosRESUMEN
Escherichia coli that produce plasmid-mediated AmpC beta-lactamases are rare in the United States. The clinical features associated with infection with these organisms have not been well described. We identified 2 clinical isolates of E. coli that produced the plasmid-mediated AmpC enzyme beta-lactamase CMY-2. These organisms were recovered from urine specimens and were resistant to ceftazidime, ceftriaxone, and cefepime. One isolate was resistant to ertapenem but susceptible to imipenem and meropenem; the other was susceptible to imipenem, meropenem, and ertapenem. One of the 2 infected patients did not require specific therapy; the other required imipenem for cure. The presence of the CMY-2 beta-lactamase was confirmed by DNA sequencing. Hybridization studies confirmed that the bla(CMY-2) gene was on a plasmid in both isolates; in one of them, the probe also hybridized with chromosomal DNA. Infection with plasmid-mediated AmpC beta-lactamases in E. coli in the United States may be associated with treatment failure, and these strains may become a serious nosocomial threat.
Asunto(s)
Proteínas Bacterianas , Escherichia coli/enzimología , Escherichia coli/genética , Plásmidos/genética , Resistencia betalactámica/genética , beta-Lactamasas/genética , beta-Lactamasas/metabolismo , Adulto , Western Blotting , Resistencia a las Cefalosporinas/genética , Conjugación Genética/genética , Electroforesis en Gel de Campo Pulsado , Escherichia coli/efectos de los fármacos , Escherichia coli/aislamiento & purificación , Infecciones por Escherichia coli/tratamiento farmacológico , Proteínas de Escherichia coli/análisis , Proteínas de Escherichia coli/genética , Proteínas de Escherichia coli/inmunología , Femenino , Amplificación de Genes , Humanos , Imipenem/metabolismo , Imipenem/uso terapéutico , Masculino , Pruebas de Sensibilidad Microbiana , Hibridación de Ácido Nucleico , Plásmidos/metabolismo , Reacción en Cadena de la Polimerasa , Análisis de Secuencia de ADN , beta-Lactamasas/análisis , beta-Lactamasas/inmunologíaRESUMEN
Linezolid is a new oxazolidinone antibiotic used to treat infections caused by vancomycin-resistant enterococci (VRE). In early clinical trials, emergence of resistance occurred rarely. We report clinical details and antibiotic susceptibility from five patients treated with linezolid for VRE infections who had resistant organisms isolated during therapy. Four were transplant patients receiving protracted courses of the drug; three cases were associated with treatment failure. One of 45 linezolid-treated patients developed resistance during therapy. Susceptibility testing should be done in all cases on starting therapy.
Asunto(s)
Acetamidas/uso terapéutico , Antibacterianos/farmacología , Antibacterianos/uso terapéutico , Enterococcus faecium/efectos de los fármacos , Infecciones por Bacterias Grampositivas/tratamiento farmacológico , Oxazolidinonas/uso terapéutico , Vancomicina/farmacología , Acetamidas/farmacología , Adulto , Anciano , Farmacorresistencia Microbiana , Humanos , Linezolid , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Oxazolidinonas/farmacologíaRESUMEN
Seedling, seedling parts and callus cultures of onion were tested for their antidiabetic activity by feeding the tissue-extracts to diabetic rats. The results indicated much higher antidiabetic activity in callus cultures as compared to natural bulbs of onion. These results may be of pharmaceutical significance since the callus can be used as an alternative source for the isolation of antidiabetic compounds.
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Diabetes Mellitus Experimental/tratamiento farmacológico , Hipoglucemiantes/farmacología , Cebollas/química , Proteínas de Plantas/farmacología , Animales , Glucemia/análisis , Diabetes Mellitus Experimental/inducido químicamente , Masculino , Ratas , Ratas WistarRESUMEN
The prevalence of rotavirus diarrhea was compared in two settings, among children attending outpatient clinics and those hospitalized (inpatients) at Pune, India. A total of 489 and 628 fecal specimens were collected during October 1993 to September 1996 from outpatients and inpatients respectively. Overall occurrence of rotavirus diarrhea was more among hospitalized children. Using the stratification on the variable age, it is shown that age is indeed a confounding variable. The important finding of the study was, in < or = 6 months age group, it was observed that the occurrence of rotavirus diarrhea was more in the outpatients (30.26%) than among the inpatients (10.11%). Children of this age group are likely to be partially protected by maternal antibodies. The effect of seasonality and sex distribution did not differ in the two settings. It was found that G2 serotype was the major cause of diarrhea among the outpatients.
Asunto(s)
Diarrea/epidemiología , Pacientes Internos/estadística & datos numéricos , Pacientes Ambulatorios/estadística & datos numéricos , Infecciones por Rotavirus/epidemiología , Instituciones de Atención Ambulatoria , Femenino , Hospitalización , Humanos , India/epidemiología , Masculino , PrevalenciaRESUMEN
During the latent phase of human immunodeficiency virus type 1 (HIV-1) infection, CD4+ T cells carrying replication-competent proviral HIV-1 DNA play an important role in persistence of the virus. Several cofactors can induce and or amplify HIV-1 replication and negatively affect disease progression and pathogenesis. Ethanol consumption is an important risk factor for HIV-1 infection, and it has been implicated in increased HIV-1 replication and progression of infection. Because tumor necrosis factor-alpha (TNF-alpha) is an important modulator of HIV-1 replication, in the present study we examined the possible effects of ethanol on TNF-alpha-inducible signaling associated with HIV-1 replication in human CD4+ T cells (Jurkat E6-1). We demonstrate that clinically relevant ethanol concentrations significantly potentiate TNF-alpha-inducible NFkappaB. Although ethanol effectively collaborated with TNF-alpha, by itself it did not have a direct effect on NFkappaB activation. The ethanol-dependent potentiation of TNF-alpha-inducible NFkappaB nuclear translocation was observed to involve the enhanced degradation of IkappaBalpha. Additionally, the ethanol-mediated potentiation of TNF-alpha-inducible NFkappaB activation was abrogated by the known antioxidant pyrrolidinedithiocarbamate, suggesting an important mechanistic role for reactive oxygen species in this process. In correspondence with its effect on NFkappaB, ethanol was also observed to significantly enhance HIV-1 long terminal repeat-dependent transcription induced by TNF-alpha. Overall, the data provide a molecular basis for the possible role of ethanol as a cofactor that can adversely affect HIV-1 infection and pathogenesis.
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Etanol/farmacología , Duplicado del Terminal Largo de VIH/efectos de los fármacos , VIH-1/genética , Proteínas I-kappa B , FN-kappa B/metabolismo , Transcripción Genética/efectos de los fármacos , Factor de Necrosis Tumoral alfa/farmacología , Cicloheximida/farmacología , Proteínas de Unión al ADN/metabolismo , Sinergismo Farmacológico , Humanos , Células Jurkat , Inhibidor NF-kappaB alfa , Prolina/análogos & derivados , Prolina/farmacología , Tiocarbamatos/farmacologíaAsunto(s)
Antibacterianos/farmacología , Resistencia a la Meticilina , Infecciones Estafilocócicas/microbiología , Staphylococcus aureus/efectos de los fármacos , Staphylococcus aureus/genética , Niño , Infecciones Comunitarias Adquiridas/epidemiología , Infecciones Comunitarias Adquiridas/microbiología , Electroforesis en Gel de Campo Pulsado , Humanos , Pruebas de Sensibilidad Microbiana , Infecciones Estafilocócicas/epidemiología , Staphylococcus aureus/clasificaciónRESUMEN
The role of apolipoproteinE (apoE) phenotypes in modulating the plasma lipid and lipoprotein levels was studied in a group of NIDDM patients and healthy individuals residing in Mumbai. The apoE phenotype frequencies were similar in the diabetic and healthy persons. The elevations in the lipid/lipoprotein levels were higher in diabetic subjects (53.3%) than in the controls (8%), showing the frequency of increase to be highest in the apoE4/4 group of diabetics, followed by apoE4/3 and apoE3/2 groups. In the controls as well, a similar trend was observed in different groups, indicating that the susceptibility to changes in lipid concentrations differs among apoE phenotypes. The apoE3/3 bearing individuals in both the categories showed close to normal lipid levels, suggesting it to be the wild type. The occurrence of apoE4 allele was higher than the apoE2 allele in diabetic individuals. Diabetic subjects with the apoE4 allele showed hypercholesterolemia, while those with apoE2 showed the presence of hypertriglyceridemia. One of the striking features of our work is a significant relationship between apoE4/3 phenotype in NIDDM persons and elevated levels of plasma triglyceride, thus suggesting a delayed catabolism of VLDL relative to production. In conclusion, the work suggests that the apoE2 and apoE4 alleles are associated with elevations in lipid levels and these changes are more pronounced in the diabetic individuals in whom most of the lipid levels were higher, indicating a gene environment/disease interaction.
Asunto(s)
Apolipoproteínas E/genética , Diabetes Mellitus Tipo 2/sangre , Diabetes Mellitus Tipo 2/genética , Lípidos/sangre , Lipoproteínas/sangre , Polimorfismo Genético , Adulto , Estudios de Casos y Controles , Colesterol/sangre , HDL-Colesterol/sangre , LDL-Colesterol/sangre , VLDL-Colesterol/sangre , Femenino , Humanos , India , Masculino , Persona de Mediana Edad , Fenotipo , Valores de Referencia , Triglicéridos/sangreRESUMEN
Immunologically committed lymphocytes, especially mature, leukemic B cells, proliferate then accumulate without further cell division in chronic lymphocytic leukemia patients (CLL). These mature, leukemic B cells often produce autoantibodies. Under normal circumstances, immunologically committed lymphocytes that are autoreactive are deleted by a programmed cell death mechanism. In CLL cells, these mechanisms appear to be inhibited; therefore, cells accumulate rather than be destroyed. To understand the mechanism by which cell survival is selected over death in CLL cells, we studied the role of beta2 integrins and their ligands in the regulation of apoptosis. CLL cells were treated with monoclonal antibodies directed against beta2 integrins. Antibodies directed against the I-domain of the alpha chain of CD11b/CD18 inhibited apoptosis. The identity of the physiological ligand or counter-receptor for beta2 integrins that was required for the inhibition of apoptosis induction was sought. The ligand iC3b, but not ICAM-1 or fibrinogen, was identified as a ligand that could prevent apoptosis of CLL B cells. Free iC3b levels were elevated in CLL patients indicating that this ligand is available in vivowhere it may interact with beta2 integrins on CLL B cells and sustain their viability by preventing activation of the programmed cell death pathway. Leukemia (2000) 14, 34-39.
Asunto(s)
Apoptosis/fisiología , Linfocitos B/patología , Antígenos CD18/fisiología , Leucemia Linfocítica Crónica de Células B/patología , Animales , Linfocitos B/inmunología , Supervivencia Celular/fisiología , Humanos , Inmunofenotipificación , Leucemia Linfocítica Crónica de Células B/inmunología , Ratones , Células Tumorales CultivadasRESUMEN
Group A rotavirus-positive stool specimens, collected from 432 hospitalized patients of all age groups with diarrhoea during 1990-1997 from Pune, India, were characterized for subgroups (SGs) and G serotypes (1, 2, 3, 4, 6, 8, and 10). ELISA for subgrouping was carried out by employing subgroup I and II-specific monoclonal antibodies (MAbs). For serotyping, MAbs against G1 (Ku), G2 (S2), G3 (Yo), and G4 (ST-3) were used. In addition, MAbs against G3 (RV-3), G8 (B37), G6 (bovine U.K.), and G10 (B223) were also employed. Of the 432 specimens, 174 (40.27%) belonged to subgroup I, 187 (43.29%) to subgroup II, 15 (3.47%) to subgroup I and II, and 56 (12.96%) did not react to MAbs specific to subgroup I and subgroup II MAbs. Of the 432 specimens, 111 (25.69%) reacted to one of the MAbs used. Thirty-five of the 111 specimens were serotyped as G1, 34 as G2, and 42 as G3, G4, G6, G8, and G10. Sixty-seven (21%) specimens gave dual reaction mainly to MAbs against G6, G10; G2, and G4, and in several other combinations. Forty-seven specimens (10.88%) showed multireactivities. A large number of specimens (47.92%) did not show any reactivity with MAbs employed in this study, and remained non-serotypeable. Subgroup I was found to be more common in Pune, and most specimens negative for subgroup I and II were non-serotypeable. The results implicate the need for characterization of unusual and non-typeable strains before undertaking any rotaviral vaccine studies in India.
Asunto(s)
Diarrea/virología , Infecciones por Rotavirus/epidemiología , Rotavirus/clasificación , Adolescente , Adulto , Anticuerpos Antivirales/análisis , Niño , Preescolar , Diarrea/epidemiología , Ensayo de Inmunoadsorción Enzimática , Heces/virología , Humanos , India , Lactante , Rotavirus/aislamiento & purificación , Infecciones por Rotavirus/virología , Serotipificación , VacunaciónRESUMEN
Rotavirus was detected in 266 (28.15%) out of 945 faecal specimens collected between July 1992 and June 1996 from children < or = 5 yr of age. Statistical analysis using odds ratios and multivariate logistic regression analysis revealed that seasonality had a strong influence on the number of rotavirus diarrhoea cases admitted to the hospital. Maximum cases occurred in the winter and minimum in the rainy season. Age was strongly associated with the prevalence of rotavirus diarrhoea. The age group of 6-24 months was the most susceptible. This disease was more predominant in males.