RESUMEN
This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.
Asunto(s)
Adyuvantes Farmacéuticos/farmacología , Curcumina/análogos & derivados , Curcumina/farmacocinética , Inhibidores Enzimáticos/farmacocinética , Absorción Intestinal , Intestino Delgado/metabolismo , 2,4-Dinitrofenol/farmacocinética , Transportadoras de Casetes de Unión a ATP/antagonistas & inhibidores , Animales , Cromatografía Líquida de Alta Presión/métodos , Curcumina/química , Diarilheptanoides , Emulsiones , Femenino , Absorción Intestinal/efectos de los fármacos , Intestino Delgado/efectos de los fármacos , Masculino , Proteína 2 Asociada a Resistencia a Múltiples Medicamentos , Proteínas Asociadas a Resistencia a Múltiples Medicamentos/análisis , Proteínas Asociadas a Resistencia a Múltiples Medicamentos/antagonistas & inhibidores , Imagen de Perfusión/métodos , Probenecid/farmacología , Ratas Sprague-Dawley , Valores de Referencia , Reproducibilidad de los Resultados , Factores de Tiempo , Desacopladores/farmacología , Verapamilo/farmacologíaRESUMEN
This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.